Self-assembly of electrospun nanofibers into gradient honeycomb structures

Tianyu Yao, Honglin Chen, Pinak Samal, Stefan Giselbrecht, Matthew B. Baker, Lorenzo Moroni*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

22 Citations (Web of Science)

Abstract

The self-assembly approach is a technically simple, rapid, and direct way to realize selective deposition of electrospun nanofibers. In the present study, we aimed to fabricate gradient polycaprolactone (PCL) honeycomb meshes by electrospinning. We demonstrated for the first time the ability to effectively fabricate a self-assembled gradient honeycomb pattern in electrospun meshes. Different honeycomb patterns were successfully fabricated by controlling the electrospinning conditions. The working distance was found to be the most important factor for the formation of gradient honeycomb structures. At a smaller working distance of 12 cm, gradients honeycomb patterns were successfully fabricated. The pore diameter of the obtained gradient honeycomb structures spanned a range from 800 mu m to 300 mu m. The average depth of gradient honeycomb was 123 +/- 56 mu m. These findings are interesting and particularly useful for us to optimize the design of gradients honeycomb scaffolds for interface tissue regeneration. (c) 2019 The Authors. Published by Elsevier Ltd.

Original languageEnglish
Article number107614
Pages (from-to)1-8
Number of pages8
JournalMaterials & design
Volume168
DOIs
Publication statusPublished - 15 Apr 2019

Keywords

  • Electrospun
  • Self-assembly
  • Gradient
  • Honeycomb
  • POLYMER NANOFIBERS
  • PORE-SIZE
  • INTRACELLULAR DELIVERY
  • DIFFERENTIATION
  • FIBERS
  • FABRICATION
  • SURFACE
  • CELLS
  • SCAFFOLDS
  • PATTERNS

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