Selective modulation of interhemispheric connectivity by transcranial alternating current stimulation influences binaural integration

Basil C Preisig*, Lars Riecke, Matthias J Sjerps, Anne Kösem, Benjamin R Kop, Bob Bramson, Peter Hagoort, Alexis Hervais-Adelman

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

6 Citations (Web of Science)

Abstract

Brain connectivity plays a major role in the encoding, transfer, and integration of sensory information. Interregional synchronization of neural oscillations in the γ-frequency band has been suggested as a key mechanism underlying perceptual integration. In a recent study, we found evidence for this hypothesis showing that the modulation of interhemispheric oscillatory synchrony by means of bihemispheric high-density transcranial alternating current stimulation (HD-TACS) affects binaural integration of dichotic acoustic features. Here, we aimed to establish a direct link between oscillatory synchrony, effective brain connectivity, and binaural integration. We experimentally manipulated oscillatory synchrony (using bihemispheric γ-TACS with different interhemispheric phase lags) and assessed the effect on effective brain connectivity and binaural integration (as measured with functional MRI and a dichotic listening task, respectively). We found that TACS reduced intrahemispheric connectivity within the auditory cortices and antiphase (interhemispheric phase lag 180°) TACS modulated connectivity between the two auditory cortices. Importantly, the changes in intra- and interhemispheric connectivity induced by TACS were correlated with changes in perceptual integration. Our results indicate that γ-band synchronization between the two auditory cortices plays a functional role in binaural integration, supporting the proposed role of interregional oscillatory synchrony in perceptual integration.

Original languageEnglish
Article number2015488118
Pages (from-to)1-11
Number of pages11
JournalProceedings of the National Academy of Sciences of the United States of America
Volume118
Issue number7
DOIs
Publication statusPublished - 16 Feb 2021

Keywords

  • speech perception
  • transcranial alternating current stimulation
  • fMRI
  • dynamic causal modeling
  • dichotic listening
  • CORPUS-CALLOSUM
  • PHASE SYNCHRONIZATION
  • SPEECH
  • COMMUNICATION
  • BRAIN
  • CORTEX
  • SPECIALIZATION
  • ATTENTION
  • ORGANIZATION
  • ENTRAINMENT

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