SAR and scan-time optimized 3D whole-brain double inversion recovery imaging at 7T

Eberhard D Pracht, Thorsten Feiweier, Philipp Ehses, Daniel Brenner, Alard Roebroeck, Bernd Weber, Tony Stöcker

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

PURPOSE: The aim of this project was to implement an ultra-high field (UHF) optimized double inversion recovery (DIR) sequence for gray matter (GM) imaging, enabling whole brain coverage in short acquisition times ( ≈5 min, image resolution 1 mm(3) ).

METHODS: A 3D variable flip angle DIR turbo spin echo (TSE) sequence was optimized for UHF application. We implemented an improved, fast, and specific absorption rate (SAR) efficient TSE imaging module, utilizing improved reordering. The DIR preparation was tailored to UHF application. Additionally, fat artifacts were minimized by employing water excitation instead of fat saturation.

RESULTS: GM images, covering the whole brain, were acquired in 7 min scan time at 1 mm isotropic resolution. SAR issues were overcome by using a dedicated flip angle calculation considering SAR and SNR efficiency. Furthermore, UHF related artifacts were minimized.

CONCLUSION: The suggested sequence is suitable to generate GM images with whole-brain coverage at UHF. Due to the short total acquisition times and overall robustness, this approach can potentially enable DIR application in a routine setting and enhance lesion detection in neurological diseases. Magn Reson Med, 2017. © 2017 International Society for Magnetic Resonance in Medicine.

Original languageEnglish
Pages (from-to)2620-2628
Number of pages9
JournalMagnetic Resonance in Medicine
Volume79
Issue number5
DOIs
Publication statusPublished - May 2018

Keywords

  • Journal Article
  • FAST-SPIN-ECHO
  • FLIP ANGLES
  • WHITE-MATTER
  • SAR
  • PULSE SEQUENCE
  • DIR
  • INTRACORTICAL LESIONS
  • UHF
  • MULTIPLE-SCLEROSIS
  • TESLA
  • MAGNETIC-RESONANCE
  • EPG
  • SPATIAL-RESOLUTION
  • GRAY-MATTER

Cite this

Pracht, E. D., Feiweier, T., Ehses, P., Brenner, D., Roebroeck, A., Weber, B., & Stöcker, T. (2018). SAR and scan-time optimized 3D whole-brain double inversion recovery imaging at 7T. Magnetic Resonance in Medicine, 79(5), 2620-2628. https://doi.org/10.1002/mrm.26913