S100B urine concentrations in late preterm infants are gestational age and gender dependent

Andrea Sannia, Francesco Maria Risso, Luc J. I. Zimmermann, Antonio W. D. Gavilanes, Hans J. Vles, Diego Gazzolo*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Background: Late preterm deliveries (LP, between 34 and 36 wks), have considerably increased in the last decades. About 20-25% of LP infants who require intensive care and morbidity on public health are of great magnitude. Therefore, we aimed at offering a reference curve in LP period of a well-established neurotrophic and brain damage marker namely S100B protein. Methods: We collected, between December 2009 and March 2012, urine samples, at first void (within 6-hours from birth) for S100B assessment, in 277 healthy LP infants consecutively admitted to our units. Standard clinical and laboratory monitoring parameters were also recorded. S100B was measured by using a commercially available immunoluminometric assay. Results: S100B pattern in LP infants was characterized by a slight decrease in protein's concentration from 34 to 35 wks. From 35 wks onwards S100B started to increase reaching a significant difference (P = 0.008) at 36 wks. When corrected for gender, significantly higher (P
Original languageEnglish
Pages (from-to)31-34
JournalClinica Chimica Acta
Publication statusPublished - 18 Feb 2013


  • S100B
  • Biomarkers
  • Late-preterm
  • Brain development

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