Rotors Detected by Phase Analysis of Filtered, Epicardial Atrial Fibrillation Electrograms Colocalize With Regions of Conduction Block

Piotr Podziemski, Stef Zeemering, Pawel Kuklik, Arne van Hunnik, Bart Maesen, Jos Maessen, Harry J. Crijns, Sander Verheule, Ulrich Schotten*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

31 Citations (Web of Science)

Abstract

BACKGROUND: Several recent studies suggest rotors detected by phase mapping may act as main drivers of persistent atrial fibrillation. However, the electrophysiological nature of detected rotors remains unclear. We performed a direct, 1:1 comparison between phase and activation time mapping in high-density, epicardial, direct-contact mapping files of human atrial fibrillation. METHODS: Thirty-eight unipolar electrogram files of 10 s duration were recorded in patients with atrial fibrillation (n=20 patients) using a 16x16 electrode array placed on the epicardial surface of the left atrial posterior wall or the right atrial free wall. Phase maps and isochrone wave maps were constructed for all recordings. For each detected phase singularity (PS) with a lifespan of >1 cycle length, the corresponding conduction pattern was investigated in the isochrone wave maps. RESULTS: When using sinusoidal recomposition and Hilbert Transform, 138 PSs were detected. One hundred and four out of 138 PSs were detected within 1 electrode distance (1.5 mm) from a line of conduction block between nonrotating wavefronts detected by activation mapping. Far fewer rotating wavefronts were detected when rotating activity was identified based on wave mapping (18 out of 8219 detected waves). Fourteen out of these 18 cases were detected as PSs in phase mapping. Phase analysis of filtered electrograms produced by simulated wavefronts separated by conduction block also identified PSs on the line of conduction block. CONCLUSIONS: PSs identified by phase analysis of filtered epicardial electrograms colocalize with conduction block lines identified by activation mapping. Detection of PSs using phase analysis has a low specificity for identifying rotating wavefronts during human atrial fibrillation using activation mapping.
Original languageEnglish
Article numbere005858
Number of pages12
JournalCirculation-Arrhythmia and Electrophysiology
Volume11
Issue number10
DOIs
Publication statusPublished - 1 Oct 2018

Keywords

  • arrhythmias, cardiac
  • atrial fibrillation
  • catheter ablation
  • computational modeling
  • electrophysiology
  • rotor
  • CARDIAC FIBRILLATION
  • FOCAL IMPULSE
  • HUMAN HEART
  • CONVENTIONAL ABLATION
  • LATE RECURRENCE
  • PERSISTENT
  • MECHANISM
  • MODEL
  • ORGANIZATION
  • MODULATION
  • ACTIVATION
  • DRIVERS
  • DYNAMICS

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