Role of TRPV1 and TRPA1 Ion Channels in Inflammatory Bowel Diseases: Potential Therapeutic Targets?

Kata Cseko, Bram Beckers, Daniel Keszthelyi, Zsuzsanna Helyes*

*Corresponding author for this work

Research output: Contribution to journal(Systematic) Review article peer-review

29 Citations (Web of Science)

Abstract

Inflammatory bowel diseases (IBD) have long been recognized to be accompanied by pain resulting in high morbidity. Transient receptor potential vanilloid 1 (TRPV1) and ankyrin 1 (TRPA1) ion channels located predominantly on the capsaicin-sensitive sensory neurons play a complex role in hyperalgesia and neurogenic inflammation. This review provides an overview of their expression and role in intestinal inflammation, in particular colitis, that appears to be virtually inconsistent based on the thorough investigations of the last twenty years. However, preclinical results with pharmacological interventions, as well as scarcely available human studies, more convincingly point out the potential therapeutic value of TRPV1 and TRPA1 antagonists in colitis and visceral hypersensitivity providing future therapeutical perspectives through a complex, unique mechanism of action for drug development in IBD.

Original languageEnglish
Article number48
Pages (from-to)1-19
Number of pages19
JournalPharmaceuticals
Volume12
Issue number2
DOIs
Publication statusPublished - Jun 2019

Keywords

  • IDB
  • Crohn's disease
  • ulcerative colitis
  • TRPV1
  • TRPA1
  • human studies
  • animal studies
  • colitis models
  • SODIUM-INDUCED COLITIS
  • VANILLOID RECEPTOR TRPV1
  • IBS-LIKE SYMPTOMS
  • ULCERATIVE-COLITIS
  • DOUBLE-BLIND
  • ANKYRIN 1
  • VISCERAL HYPERSENSITIVITY
  • PROTECTIVE ROLE
  • MICE DEFICIENT
  • UP-REGULATION

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