Role of Progressive Widening of the Temporal Excitable Gap for Perpetuation of Atrial Fibrillation in the Goat

Zhaoliang Shan; Junjin Yan; Junyan Zhou; Xiangmin Shi; Jianping Guo; Hongtao Yuan; Maurits A. Allessie; Yutang Wang

doi:10.1253/circj.CJ-09-0596

Role of Progressive Widening of the Temporal Excitable Gap for Perpetuation of Atrial Fibrillation in the Goat

Zhaoliang Shan, Junjin Yan, Junyan Zhou, Xiangmin Shi, Jianping Guo, Hongtao Yuan, Maurits A. Allessie, Yutang Wang^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Background: Previous studies suggest that a short temporal excitable gap exists between the fibrillation waves during atrial fibrillation (AF). The aim of this study was to investigate the role of that gap in the development of sustained AF in goats. Methods and Results: Eight female goats were instrumented with left atrium (LA) electrodes, and sustained AF (>24 h) was induced by intermittent rapid atrial pacing for 9.3 +/- 4.6 days. In the process of sustained AF development, the atrial effective refractory period (AERP), refractory period during AF (RPAF), mean AF cycle length (AFCL), temporal excitable gap during AF (EG(AF)=AFCL-RPAF) and degree of fractionation of fibrillation electrograms at LA were studied. When the induced AF lasted for 3-10min, AFCL, RPAF and EG(AF) were 98.3 +/- 11.0 ms, 90.5 +/- 13.2 ms and 7.8 +/- 2.4 ms, respectively. During sustained AF, the values were 84.9 +/- 5.2 ms, 63.0 +/- 4.8 ms and 21.9 +/- 3.5ms, respectively (P

Original language	English
Pages (from-to)	655-663
Journal	Circulation Journal
Volume	74
Issue number	4
DOIs	https://doi.org/10.1253/circj.CJ-09-0596
Publication status	Published - Apr 2010

Keywords

Atrial fibrillation
Atrium
Electrophysiology
Remodeling

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10.1253/circj.CJ-09-0596

Cite this

@article{63b6ddb7ae6a4ad29cbf48dfff094aaa,

title = "Role of Progressive Widening of the Temporal Excitable Gap for Perpetuation of Atrial Fibrillation in the Goat",

abstract = "Background: Previous studies suggest that a short temporal excitable gap exists between the fibrillation waves during atrial fibrillation (AF). The aim of this study was to investigate the role of that gap in the development of sustained AF in goats. Methods and Results: Eight female goats were instrumented with left atrium (LA) electrodes, and sustained AF (>24 h) was induced by intermittent rapid atrial pacing for 9.3 +/- 4.6 days. In the process of sustained AF development, the atrial effective refractory period (AERP), refractory period during AF (RPAF), mean AF cycle length (AFCL), temporal excitable gap during AF (EG(AF)=AFCL-RPAF) and degree of fractionation of fibrillation electrograms at LA were studied. When the induced AF lasted for 3-10min, AFCL, RPAF and EG(AF) were 98.3 +/- 11.0 ms, 90.5 +/- 13.2 ms and 7.8 +/- 2.4 ms, respectively. During sustained AF, the values were 84.9 +/- 5.2 ms, 63.0 +/- 4.8 ms and 21.9 +/- 3.5ms, respectively (P",

keywords = "Atrial fibrillation, Atrium, Electrophysiology, Remodeling",

author = "Zhaoliang Shan and Junjin Yan and Junyan Zhou and Xiangmin Shi and Jianping Guo and Hongtao Yuan and Allessie, {Maurits A.} and Yutang Wang",

year = "2010",

month = apr,

doi = "10.1253/circj.CJ-09-0596",

language = "English",

volume = "74",

pages = "655--663",

journal = "Circulation Journal",

issn = "1346-9843",

publisher = "Japanese Circulation Society",

number = "4",

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TY - JOUR

T1 - Role of Progressive Widening of the Temporal Excitable Gap for Perpetuation of Atrial Fibrillation in the Goat

AU - Shan, Zhaoliang

AU - Yan, Junjin

AU - Zhou, Junyan

AU - Shi, Xiangmin

AU - Guo, Jianping

AU - Yuan, Hongtao

AU - Allessie, Maurits A.

AU - Wang, Yutang

PY - 2010/4

Y1 - 2010/4

N2 - Background: Previous studies suggest that a short temporal excitable gap exists between the fibrillation waves during atrial fibrillation (AF). The aim of this study was to investigate the role of that gap in the development of sustained AF in goats. Methods and Results: Eight female goats were instrumented with left atrium (LA) electrodes, and sustained AF (>24 h) was induced by intermittent rapid atrial pacing for 9.3 +/- 4.6 days. In the process of sustained AF development, the atrial effective refractory period (AERP), refractory period during AF (RPAF), mean AF cycle length (AFCL), temporal excitable gap during AF (EG(AF)=AFCL-RPAF) and degree of fractionation of fibrillation electrograms at LA were studied. When the induced AF lasted for 3-10min, AFCL, RPAF and EG(AF) were 98.3 +/- 11.0 ms, 90.5 +/- 13.2 ms and 7.8 +/- 2.4 ms, respectively. During sustained AF, the values were 84.9 +/- 5.2 ms, 63.0 +/- 4.8 ms and 21.9 +/- 3.5ms, respectively (P

AB - Background: Previous studies suggest that a short temporal excitable gap exists between the fibrillation waves during atrial fibrillation (AF). The aim of this study was to investigate the role of that gap in the development of sustained AF in goats. Methods and Results: Eight female goats were instrumented with left atrium (LA) electrodes, and sustained AF (>24 h) was induced by intermittent rapid atrial pacing for 9.3 +/- 4.6 days. In the process of sustained AF development, the atrial effective refractory period (AERP), refractory period during AF (RPAF), mean AF cycle length (AFCL), temporal excitable gap during AF (EG(AF)=AFCL-RPAF) and degree of fractionation of fibrillation electrograms at LA were studied. When the induced AF lasted for 3-10min, AFCL, RPAF and EG(AF) were 98.3 +/- 11.0 ms, 90.5 +/- 13.2 ms and 7.8 +/- 2.4 ms, respectively. During sustained AF, the values were 84.9 +/- 5.2 ms, 63.0 +/- 4.8 ms and 21.9 +/- 3.5ms, respectively (P

KW - Atrial fibrillation

KW - Atrium

KW - Electrophysiology

KW - Remodeling

U2 - 10.1253/circj.CJ-09-0596

DO - 10.1253/circj.CJ-09-0596

M3 - Article

SN - 1346-9843

VL - 74

SP - 655

EP - 663

JO - Circulation Journal

JF - Circulation Journal

IS - 4

ER -