Role of Progressive Widening of the Temporal Excitable Gap for Perpetuation of Atrial Fibrillation in the Goat

Zhaoliang Shan, Junjin Yan, Junyan Zhou, Xiangmin Shi, Jianping Guo, Hongtao Yuan, Maurits A. Allessie, Yutang Wang*

*Corresponding author for this work

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Background: Previous studies suggest that a short temporal excitable gap exists between the fibrillation waves during atrial fibrillation (AF). The aim of this study was to investigate the role of that gap in the development of sustained AF in goats. Methods and Results: Eight female goats were instrumented with left atrium (LA) electrodes, and sustained AF (>24 h) was induced by intermittent rapid atrial pacing for 9.3 +/- 4.6 days. In the process of sustained AF development, the atrial effective refractory period (AERP), refractory period during AF (RPAF), mean AF cycle length (AFCL), temporal excitable gap during AF (EG(AF)=AFCL-RPAF) and degree of fractionation of fibrillation electrograms at LA were studied. When the induced AF lasted for 3-10min, AFCL, RPAF and EG(AF) were 98.3 +/- 11.0 ms, 90.5 +/- 13.2 ms and 7.8 +/- 2.4 ms, respectively. During sustained AF, the values were 84.9 +/- 5.2 ms, 63.0 +/- 4.8 ms and 21.9 +/- 3.5ms, respectively (P
Original languageEnglish
Pages (from-to)655-663
JournalCirculation Journal
Issue number4
Publication statusPublished - Apr 2010


  • Atrial fibrillation
  • Atrium
  • Electrophysiology
  • Remodeling

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