Roadmap for Precision preclinical x-ray radiation studies

Frank Verhaegen*, Karl T Butterworth, Anthony J Chalmers, Rob P Coppes, Dirk de Ruysscher, Sophie Dobiasch, John D Fenwick, Patrick V Granton, Stefan H J Heijmans, Mark A Hill, Constantinos Koumenis, Kirsten Lauber, Brian Marples, Katia Parodi, Lucas C G G Persoon, Nick Staut, Anna Subiel, Rianne D W Vaes, Stefan J van Hoof, Ioannis L VerginadisJan J Wilkens, Kaye J Williams, George D Wilson, Ludwig J Dubois

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


This Roadmap paper covers the field of precision preclinical radiation studies in animal models. It is mostly focused on models for cancer and normal tissue response to radiation, but also discusses other disease models. The recent technological evolutions in imaging, irradiation, dosimetry and monitoring that have empowered these kinds of studies is discussed, and many developments in the near future are outlined. Finally, clinical translation and inverse translation are discussed.

Original languageEnglish
Article number06RM01
Number of pages41
JournalPhysics in Medicine and Biology
Issue number6
Early online date30 Dec 2022
Publication statusPublished - 21 Mar 2023


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