Roadmap for Precision preclinical x-ray radiation studies

Frank Verhaegen; Karl T Butterworth; Anthony J Chalmers; Rob P Coppes; Dirk de Ruysscher; Sophie Dobiasch; John D Fenwick; Patrick V Granton; Stefan H J Heijmans; Mark A Hill; Constantinos Koumenis; Kirsten Lauber; Brian Marples; Katia Parodi; Lucas C G G Persoon; Nick Staut; Anna Subiel; Rianne D W Vaes; Stefan J van Hoof; Ioannis L Verginadis; Jan J Wilkens; Kaye J Williams; George D Wilson; Ludwig J Dubois

doi:10.1088/1361-6560/acaf45

Roadmap for Precision preclinical x-ray radiation studies

Frank Verhaegen^*, Karl T Butterworth, Anthony J Chalmers, Rob P Coppes, Dirk de Ruysscher, Sophie Dobiasch, John D Fenwick, Patrick V Granton, Stefan H J Heijmans, Mark A Hill, Constantinos Koumenis, Kirsten Lauber, Brian Marples, Katia Parodi, Lucas C G G Persoon, Nick Staut, Anna Subiel, Rianne D W Vaes, Stefan J van Hoof, Ioannis L VerginadisJan J Wilkens, Kaye J Williams, George D Wilson, Ludwig J Dubois

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

This Roadmap paper covers the field of precision preclinical radiation studies in animal models. It is mostly focused on models for cancer and normal tissue response to radiation, but also discusses other disease models. The recent technological evolutions in imaging, irradiation, dosimetry and monitoring that have empowered these kinds of studies is discussed, and many developments in the near future are outlined. Finally, clinical translation and inverse translation are discussed.

Original language	English
Article number	06RM01
Number of pages	41
Journal	Physics in Medicine and Biology
Volume	68
Issue number	6
Early online date	30 Dec 2022
DOIs	https://doi.org/10.1088/1361-6560/acaf45
Publication status	Published - 21 Mar 2023

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10.1088/1361-6560/acaf45Licence: CC BY

Cite this

Verhaegen, F., Butterworth, K. T., Chalmers, A. J., Coppes, R. P., de Ruysscher, D., Dobiasch, S., Fenwick, J. D., Granton, P. V., Heijmans, S. H. J., Hill, M. A., Koumenis, C., Lauber, K., Marples, B., Parodi, K., Persoon, L. C. G. G., Staut, N., Subiel, A., Vaes, R. D. W., van Hoof, S. J., ... Dubois, L. J. (2023). Roadmap for Precision preclinical x-ray radiation studies. Physics in Medicine and Biology, 68(6), Article 06RM01. https://doi.org/10.1088/1361-6560/acaf45

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abstract = "This Roadmap paper covers the field of precision preclinical radiation studies in animal models. It is mostly focused on models for cancer and normal tissue response to radiation, but also discusses other disease models. The recent technological evolutions in imaging, irradiation, dosimetry and monitoring that have empowered these kinds of studies is discussed, and many developments in the near future are outlined. Finally, clinical translation and inverse translation are discussed.",

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Verhaegen, F, Butterworth, KT, Chalmers, AJ, Coppes, RP, de Ruysscher, D, Dobiasch, S, Fenwick, JD, Granton, PV, Heijmans, SHJ, Hill, MA, Koumenis, C, Lauber, K, Marples, B, Parodi, K, Persoon, LCGG, Staut, N, Subiel, A, Vaes, RDW, van Hoof, SJ, Verginadis, IL, Wilkens, JJ, Williams, KJ, Wilson, GD & Dubois, LJ 2023, 'Roadmap for Precision preclinical x-ray radiation studies', Physics in Medicine and Biology, vol. 68, no. 6, 06RM01. https://doi.org/10.1088/1361-6560/acaf45

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AU - Verhaegen, Frank

AU - Butterworth, Karl T

AU - Chalmers, Anthony J

AU - Coppes, Rob P

AU - de Ruysscher, Dirk

AU - Dobiasch, Sophie

AU - Fenwick, John D

AU - Granton, Patrick V

AU - Heijmans, Stefan H J

AU - Hill, Mark A

AU - Koumenis, Constantinos

AU - Lauber, Kirsten

AU - Marples, Brian

AU - Parodi, Katia

AU - Persoon, Lucas C G G

AU - Staut, Nick

AU - Subiel, Anna

AU - Vaes, Rianne D W

AU - van Hoof, Stefan J

AU - Verginadis, Ioannis L

AU - Wilkens, Jan J

AU - Williams, Kaye J

AU - Wilson, George D

AU - Dubois, Ludwig J

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N2 - This Roadmap paper covers the field of precision preclinical radiation studies in animal models. It is mostly focused on models for cancer and normal tissue response to radiation, but also discusses other disease models. The recent technological evolutions in imaging, irradiation, dosimetry and monitoring that have empowered these kinds of studies is discussed, and many developments in the near future are outlined. Finally, clinical translation and inverse translation are discussed.

AB - This Roadmap paper covers the field of precision preclinical radiation studies in animal models. It is mostly focused on models for cancer and normal tissue response to radiation, but also discusses other disease models. The recent technological evolutions in imaging, irradiation, dosimetry and monitoring that have empowered these kinds of studies is discussed, and many developments in the near future are outlined. Finally, clinical translation and inverse translation are discussed.

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