Retinal and Renal Microvasculature in Relation to Central Hemodynamics in 11-Year-Old Children Born Preterm or At Term

Fang-Fei Wei, Anke Raaijmakers, Jesus D. Melgarejo, Nicholas Cauwenberghs, Lutgarde Thijs, Zhen-Yu Zhang, Cai-Guo Yu, Elena Levtchenko, Harry A. J. Struijker-Boudier, Wen-Yi Yang, Tatiana Kuznetsova, Sean Kennedy, Peter Verhamme, Karel Allegaert, Jan A. Staessen*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

3 Citations (Web of Science)

Abstract

Background Prematurity disrupts the perinatal maturation of the microvasculature and macrovasculature and confers high risk of vascular dysfunction later in life. No previous studies have investigated the crosstalk between the microvasculature and macrovasculature in childhood.

Methods and Results In a case-control study, we enrolled 55 children aged 11 years weighing m; 95% CI, -5.18 to -0.70 mu m [P=0.011]) and forward (-2.57 mu m; CI, -4.81 to -0.32 mu m [P=0.026]) and backward (-3.20 mu m; CI, -5.47 to -0.94 mu m [P=0.006]) wave amplitudes. Greater renal resistive index was associated with higher backward wave amplitude (0.92 mm Hg, P=0.036).

Conclusions In childhood, prematurity compared with term birth is associated with higher central systolic BP and forward/backward wave amplitudes. Higher renal resistive index likely moves reflection points closer to the heart, thereby explaining the inverse association of central retinal arteriolar equivalent with central systolic BP and backward wave amplitude. These observations highlight the crosstalk between the microcirculation and macrocirculation in children.

Registration URL: http://www.clinicaltrials.gov. Unique Identifier: NCT02147457.

Original languageEnglish
Article number014305
Number of pages17
JournalJournal of the American Heart Association
Volume9
Issue number15
DOIs
Publication statusPublished - 4 Aug 2020

Keywords

  • central hemodynamics
  • children
  • microcirculation
  • prematurity
  • retina
  • PULSE-WAVE VELOCITY
  • BLOOD-PRESSURE
  • ARTERIAL STIFFNESS
  • CARDIOVASCULAR CONSEQUENCES
  • ATHEROSCLEROSIS RISK
  • EUROPEAN-SOCIETY
  • RESISTIVE INDEX
  • REFLECTION
  • BIRTH
  • RECOMMENDATIONS

Cite this