Retinal and Renal Microvasculature in Relation to Central Hemodynamics in 11-Year-Old Children Born Preterm or At Term

Fang-Fei Wei; Anke Raaijmakers; Jesus D. Melgarejo; Nicholas Cauwenberghs; Lutgarde Thijs; Zhen-Yu Zhang; Cai-Guo Yu; Elena Levtchenko; Harry A. J. Struijker-Boudier; Wen-Yi Yang; Tatiana Kuznetsova; Sean Kennedy; Peter Verhamme; Karel Allegaert; Jan A. Staessen

doi:10.1161/JAHA.119.014305

Retinal and Renal Microvasculature in Relation to Central Hemodynamics in 11-Year-Old Children Born Preterm or At Term

Fang-Fei Wei, Anke Raaijmakers, Jesus D. Melgarejo, Nicholas Cauwenberghs, Lutgarde Thijs, Zhen-Yu Zhang, Cai-Guo Yu, Elena Levtchenko, Harry A. J. Struijker-Boudier, Wen-Yi Yang, Tatiana Kuznetsova, Sean Kennedy, Peter Verhamme, Karel Allegaert, Jan A. Staessen^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Background Prematurity disrupts the perinatal maturation of the microvasculature and macrovasculature and confers high risk of vascular dysfunction later in life. No previous studies have investigated the crosstalk between the microvasculature and macrovasculature in childhood.

Methods and Results In a case-control study, we enrolled 55 children aged 11 years weighing m; 95% CI, -5.18 to -0.70 mu m [P=0.011]) and forward (-2.57 mu m; CI, -4.81 to -0.32 mu m [P=0.026]) and backward (-3.20 mu m; CI, -5.47 to -0.94 mu m [P=0.006]) wave amplitudes. Greater renal resistive index was associated with higher backward wave amplitude (0.92 mm Hg, P=0.036).

Conclusions In childhood, prematurity compared with term birth is associated with higher central systolic BP and forward/backward wave amplitudes. Higher renal resistive index likely moves reflection points closer to the heart, thereby explaining the inverse association of central retinal arteriolar equivalent with central systolic BP and backward wave amplitude. These observations highlight the crosstalk between the microcirculation and macrocirculation in children.

Registration URL: http://www.clinicaltrials.gov. Unique Identifier: NCT02147457.

Original language	English
Article number	014305
Number of pages	17
Journal	Journal of the American Heart Association
Volume	9
Issue number	15
DOIs	https://doi.org/10.1161/JAHA.119.014305
Publication status	Published - 4 Aug 2020

Keywords

central hemodynamics
children
microcirculation
prematurity
retina
PULSE-WAVE VELOCITY
BLOOD-PRESSURE
ARTERIAL STIFFNESS
CARDIOVASCULAR CONSEQUENCES
ATHEROSCLEROSIS RISK
EUROPEAN-SOCIETY
RESISTIVE INDEX
REFLECTION
BIRTH
RECOMMENDATIONS

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Cite this

Wei, F.-F., Raaijmakers, A., Melgarejo, J. D., Cauwenberghs, N., Thijs, L., Zhang, Z.-Y., Yu, C.-G., Levtchenko, E., Struijker-Boudier, H. A. J., Yang, W.-Y., Kuznetsova, T., Kennedy, S., Verhamme, P., Allegaert, K., & Staessen, J. A. (2020). Retinal and Renal Microvasculature in Relation to Central Hemodynamics in 11-Year-Old Children Born Preterm or At Term. Journal of the American Heart Association, 9(15), Article 014305. https://doi.org/10.1161/JAHA.119.014305

@article{40c371881cad40a0942a04e5fd72c04a,

title = "Retinal and Renal Microvasculature in Relation to Central Hemodynamics in 11-Year-Old Children Born Preterm or At Term",

abstract = "Background Prematurity disrupts the perinatal maturation of the microvasculature and macrovasculature and confers high risk of vascular dysfunction later in life. No previous studies have investigated the crosstalk between the microvasculature and macrovasculature in childhood.Methods and Results In a case-control study, we enrolled 55 children aged 11 years weighing m; 95% CI, -5.18 to -0.70 mu m [P=0.011]) and forward (-2.57 mu m; CI, -4.81 to -0.32 mu m [P=0.026]) and backward (-3.20 mu m; CI, -5.47 to -0.94 mu m [P=0.006]) wave amplitudes. Greater renal resistive index was associated with higher backward wave amplitude (0.92 mm Hg, P=0.036).Conclusions In childhood, prematurity compared with term birth is associated with higher central systolic BP and forward/backward wave amplitudes. Higher renal resistive index likely moves reflection points closer to the heart, thereby explaining the inverse association of central retinal arteriolar equivalent with central systolic BP and backward wave amplitude. These observations highlight the crosstalk between the microcirculation and macrocirculation in children.Registration URL: http://www.clinicaltrials.gov. Unique Identifier: NCT02147457.",

keywords = "central hemodynamics, children, microcirculation, prematurity, retina, PULSE-WAVE VELOCITY, BLOOD-PRESSURE, ARTERIAL STIFFNESS, CARDIOVASCULAR CONSEQUENCES, ATHEROSCLEROSIS RISK, EUROPEAN-SOCIETY, RESISTIVE INDEX, REFLECTION, BIRTH, RECOMMENDATIONS",

author = "Fang-Fei Wei and Anke Raaijmakers and Melgarejo, {Jesus D.} and Nicholas Cauwenberghs and Lutgarde Thijs and Zhen-Yu Zhang and Cai-Guo Yu and Elena Levtchenko and Struijker-Boudier, {Harry A. J.} and Wen-Yi Yang and Tatiana Kuznetsova and Sean Kennedy and Peter Verhamme and Karel Allegaert and Staessen, {Jan A.}",

note = "Funding Information: The Agency for Innovation by Science and Technology in Flanders (IWT) supported PREMATCH through the SAFE-PEDRUG project (IWT/SBO 130033). The European Union (HEALTH-F7-305507-HOMAGE), the European Research Council (Advanced Researcher Grant 2011-294713-EPLORE and Proof-of-Concept Grant 713601-uPROPHET), the European Research Area Net for Cardiovascular Diseases (JTC2017-046-PROACT), and the Research Foundation Flanders, Ministry of the Flemish Community, Brussels, Belgium (G.0881.13 and 11Z0916N) supported the Studies Coordinating Centre in Leuven. The work was also supported by China Postdoctoral Science Foundation (2019M663312). The NPO Alliance for the Promotion of Preventive Medicine (htpps://www.appremed.org) received a nonbinding grant from Omron Healthcare Inc., Kyoto, Japan. Publisher Copyright: {\textcopyright} 2020 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.",

year = "2020",

month = aug,

day = "4",

doi = "10.1161/JAHA.119.014305",

language = "English",

volume = "9",

journal = "Journal of the American Heart Association",

issn = "2047-9980",

publisher = "Wiley",

number = "15",

}

Wei, F-F, Raaijmakers, A, Melgarejo, JD, Cauwenberghs, N, Thijs, L, Zhang, Z-Y, Yu, C-G, Levtchenko, E, Struijker-Boudier, HAJ, Yang, W-Y, Kuznetsova, T, Kennedy, S, Verhamme, P, Allegaert, K & Staessen, JA 2020, 'Retinal and Renal Microvasculature in Relation to Central Hemodynamics in 11-Year-Old Children Born Preterm or At Term', Journal of the American Heart Association, vol. 9, no. 15, 014305. https://doi.org/10.1161/JAHA.119.014305

TY - JOUR

T1 - Retinal and Renal Microvasculature in Relation to Central Hemodynamics in 11-Year-Old Children Born Preterm or At Term

AU - Wei, Fang-Fei

AU - Raaijmakers, Anke

AU - Melgarejo, Jesus D.

AU - Cauwenberghs, Nicholas

AU - Thijs, Lutgarde

AU - Zhang, Zhen-Yu

AU - Yu, Cai-Guo

AU - Levtchenko, Elena

AU - Struijker-Boudier, Harry A. J.

AU - Yang, Wen-Yi

AU - Kuznetsova, Tatiana

AU - Kennedy, Sean

AU - Verhamme, Peter

AU - Allegaert, Karel

AU - Staessen, Jan A.

N1 - Funding Information: The Agency for Innovation by Science and Technology in Flanders (IWT) supported PREMATCH through the SAFE-PEDRUG project (IWT/SBO 130033). The European Union (HEALTH-F7-305507-HOMAGE), the European Research Council (Advanced Researcher Grant 2011-294713-EPLORE and Proof-of-Concept Grant 713601-uPROPHET), the European Research Area Net for Cardiovascular Diseases (JTC2017-046-PROACT), and the Research Foundation Flanders, Ministry of the Flemish Community, Brussels, Belgium (G.0881.13 and 11Z0916N) supported the Studies Coordinating Centre in Leuven. The work was also supported by China Postdoctoral Science Foundation (2019M663312). The NPO Alliance for the Promotion of Preventive Medicine (htpps://www.appremed.org) received a nonbinding grant from Omron Healthcare Inc., Kyoto, Japan. Publisher Copyright: © 2020 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.

PY - 2020/8/4

Y1 - 2020/8/4

N2 - Background Prematurity disrupts the perinatal maturation of the microvasculature and macrovasculature and confers high risk of vascular dysfunction later in life. No previous studies have investigated the crosstalk between the microvasculature and macrovasculature in childhood.Methods and Results In a case-control study, we enrolled 55 children aged 11 years weighing m; 95% CI, -5.18 to -0.70 mu m [P=0.011]) and forward (-2.57 mu m; CI, -4.81 to -0.32 mu m [P=0.026]) and backward (-3.20 mu m; CI, -5.47 to -0.94 mu m [P=0.006]) wave amplitudes. Greater renal resistive index was associated with higher backward wave amplitude (0.92 mm Hg, P=0.036).Conclusions In childhood, prematurity compared with term birth is associated with higher central systolic BP and forward/backward wave amplitudes. Higher renal resistive index likely moves reflection points closer to the heart, thereby explaining the inverse association of central retinal arteriolar equivalent with central systolic BP and backward wave amplitude. These observations highlight the crosstalk between the microcirculation and macrocirculation in children.Registration URL: http://www.clinicaltrials.gov. Unique Identifier: NCT02147457.

AB - Background Prematurity disrupts the perinatal maturation of the microvasculature and macrovasculature and confers high risk of vascular dysfunction later in life. No previous studies have investigated the crosstalk between the microvasculature and macrovasculature in childhood.Methods and Results In a case-control study, we enrolled 55 children aged 11 years weighing m; 95% CI, -5.18 to -0.70 mu m [P=0.011]) and forward (-2.57 mu m; CI, -4.81 to -0.32 mu m [P=0.026]) and backward (-3.20 mu m; CI, -5.47 to -0.94 mu m [P=0.006]) wave amplitudes. Greater renal resistive index was associated with higher backward wave amplitude (0.92 mm Hg, P=0.036).Conclusions In childhood, prematurity compared with term birth is associated with higher central systolic BP and forward/backward wave amplitudes. Higher renal resistive index likely moves reflection points closer to the heart, thereby explaining the inverse association of central retinal arteriolar equivalent with central systolic BP and backward wave amplitude. These observations highlight the crosstalk between the microcirculation and macrocirculation in children.Registration URL: http://www.clinicaltrials.gov. Unique Identifier: NCT02147457.

KW - central hemodynamics

KW - children

KW - microcirculation

KW - prematurity

KW - retina

KW - PULSE-WAVE VELOCITY

KW - BLOOD-PRESSURE

KW - ARTERIAL STIFFNESS

KW - CARDIOVASCULAR CONSEQUENCES

KW - ATHEROSCLEROSIS RISK

KW - EUROPEAN-SOCIETY

KW - RESISTIVE INDEX

KW - REFLECTION

KW - BIRTH

KW - RECOMMENDATIONS

U2 - 10.1161/JAHA.119.014305

DO - 10.1161/JAHA.119.014305

M3 - Article

C2 - 32750311

SN - 2047-9980

VL - 9

JO - Journal of the American Heart Association

JF - Journal of the American Heart Association

IS - 15

M1 - 014305

ER -