Resultaten van de STAMPEDE-trial: Geloofwaardigheid en consequenties voor de praktijk

Translated title of the contribution: Result of the STAMPEDE trial; : plausibility and practical consequences

Research output: Contribution to journalEditorialAcademicpeer-review

Abstract

Recently, the results of the STAMPEDE trial arm H were reported. This trial investigated the effect of radiotherapy to the prostate only on the overall survival of patients with metastatic prostate cancer. Although on the whole the findings of the trial were negative, a significant increase in survival was noted in the prespecified subgroup of patients with a low metastatic burden. As only a few analyses were prespecified, the direction of the subgroup effect was prespecified and consistent with previous observations from the separate but comparable HORRAD trial. The subgroup effect was large and independent of other subgroup variables, and as there is a solid biological rationale for these results, they are to be considered trustworthy, and are likely to change clinical practice. Further research should focus on better specification of the low metastatic burden subgroup, if other locally ablative treatments such as surgery are equivalent, and if ablation of all metastatic lesions would give additional benefit.
Translated title of the contributionResult of the STAMPEDE trial; : plausibility and practical consequences
Original languageDutch
Article numberD3883
JournalNederlands Tijdschrift voor Geneeskunde
Volume163
Publication statusPublished - 31 May 2019

Keywords

  • Androgen Antagonists/therapeutic use
  • Antineoplastic Agents/therapeutic use
  • Disease-Free Survival
  • Humans
  • Male
  • Orchiectomy/statistics & numerical data
  • Prostatic Neoplasms/mortality radiotherapy therapy
  • Randomized Controlled Trials as Topic
  • Treatment Outcome

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