TY - JOUR
T1 - Responses of the ambulatory arterial stiffness index and other measures of arterial function to antihypertensive drugs
AU - Jin, Yu
AU - Thijs, Lutgarde
AU - Richart, Tom
AU - Li, Yan
AU - Dolan, Eamon
AU - Wang, Ji-Guang
AU - Protogerou, Athanase
AU - O'Brien, Eoin
AU - Staessen, Jan A.
AU - Safar, Michel E.
PY - 2011/4
Y1 - 2011/4
N2 - We investigated the effects of different antihypertensive drugs on the ambulatory arterial stiffness index (AASI), pulse pressure (PP), the arterio-ventricular coupling index (AVCI) and aortic pulse wave velocity (aPWV). After a 4-week placebo period, 94 and 107 patients with uncomplicated hypertension were randomly assigned to treatment with atenolol (AT) at dosage of 50 mg per day or perindopril/indapamide (PER/IND) at dosage of 2/0.6 mg per day for 1 year. From each patient's 24-h ambulatory blood pressure (BP) recording, we determined the 24-h systolic and diastolic BPs. We computed PP as the difference between 24-h systolic and diastolic BP, AASI as unity minus the regression slope of diastolic on systolic BP, and AVCI as (T/tau)/(1+2T/3 tau), where T is the heart period in seconds and tau is the decay time of aortic BP during diastole. On AT compared with PER/IND, with adjustments applied for covariables, 24-h systolic BP (-9.5 vs. -13.7mmHg; P=0.009) and 24-h PP (-1.02 vs. -6.53 mm Hg; P <0.001) decreased less and AVCI lengthened more (+0.019 vs. -0.008; P <0.001). The changes in AASI (-0.001 vs. -0.014; P-0.44) and aPWV (-0.89 vs. -0.69 ms(-1); P-0.45) were similar in the two treatment groups. AASI and aPWV showed significant concordance (r=0.21, P=0.003) after adjustment for covariables. On administration of antihypertensive drugs with different hemodynamic profiles, AASI and aPWV behaved similarly. The similarity in the findings for aPWV and AASI support the use of AASI as an index reflecting the arterial stiffness. Hypertension Research (2011) 34, 489-495; doi:10.1038/hr.2010.256; published online 13 January 2011
AB - We investigated the effects of different antihypertensive drugs on the ambulatory arterial stiffness index (AASI), pulse pressure (PP), the arterio-ventricular coupling index (AVCI) and aortic pulse wave velocity (aPWV). After a 4-week placebo period, 94 and 107 patients with uncomplicated hypertension were randomly assigned to treatment with atenolol (AT) at dosage of 50 mg per day or perindopril/indapamide (PER/IND) at dosage of 2/0.6 mg per day for 1 year. From each patient's 24-h ambulatory blood pressure (BP) recording, we determined the 24-h systolic and diastolic BPs. We computed PP as the difference between 24-h systolic and diastolic BP, AASI as unity minus the regression slope of diastolic on systolic BP, and AVCI as (T/tau)/(1+2T/3 tau), where T is the heart period in seconds and tau is the decay time of aortic BP during diastole. On AT compared with PER/IND, with adjustments applied for covariables, 24-h systolic BP (-9.5 vs. -13.7mmHg; P=0.009) and 24-h PP (-1.02 vs. -6.53 mm Hg; P <0.001) decreased less and AVCI lengthened more (+0.019 vs. -0.008; P <0.001). The changes in AASI (-0.001 vs. -0.014; P-0.44) and aPWV (-0.89 vs. -0.69 ms(-1); P-0.45) were similar in the two treatment groups. AASI and aPWV showed significant concordance (r=0.21, P=0.003) after adjustment for covariables. On administration of antihypertensive drugs with different hemodynamic profiles, AASI and aPWV behaved similarly. The similarity in the findings for aPWV and AASI support the use of AASI as an index reflecting the arterial stiffness. Hypertension Research (2011) 34, 489-495; doi:10.1038/hr.2010.256; published online 13 January 2011
KW - ambulatory arterial stiffness index
KW - ambulatory blood pressure
KW - aortic pulse wave velocity
KW - arterial stiffness
U2 - 10.1038/hr.2010.256
DO - 10.1038/hr.2010.256
M3 - Article
C2 - 21228786
SN - 0916-9636
VL - 34
SP - 489
EP - 495
JO - Hypertension Research
JF - Hypertension Research
IS - 4
ER -