Increasing evidence suggests that glutamine is important for the function of many organ systems and supports the use of glutamine-enriched total parenteral nutrition (TPN) during severe illness. However, the effect of prolonged glutamine supplementation on glutamine kinetics has not been studied.We investigated the effect of 8-10 d of TPN enriched with glutamine dipeptides on glutamine kinetics.Twenty-three preoperative patients were randomly allocated to receive either TPN enriched with glutamine dipeptides (60 micromol glutamine*kg body wt(-1)*h(-1)) or isonitrogenous, isoenergetic, glutamine-free TPN. A primed, continuous, 6-h intravenous infusion of L-[5-(15)N]glutamine and L-[1-(13)C]leucine was given before (baseline) and 8-10 d after the TPN solutions were administered. Baseline measurements were performed after a 40-h administration of a standard solution of glucose and amino acids (no glutamine).Glutamine-enriched TPN increased the total appearance rate of glutamine (P: disease.
van Acker, B. A. C., Hulsewé, K. W. E., Wagenmakers, A. J. M., von Meyenfeldt, M. F., & Soeters, P. B. (2000). Response of glutamine metabolism to glutamine-supplemented parenteral nutrition. American Journal of Clinical Nutrition, 72(3), 790-795. https://doi.org/10.1093/ajcn/72.3.790