@article{84d9a5e687254a20b15fad1e644bd12b,
title = "Research gaps and opportunities in autoimmune hepatitis-Results of the international autoimmune hepatitis group research workshop 2022",
abstract = "Autoimmune hepatitis (AIH) is a rare autoimmune liver disease that is characterised by a chronic inflammatory immune reaction directed against hepatocytes. The disease results in a substantial reduction in quality of life and potentially leads to liver-related complications or death. The International Autoimmune Hepatitis Group (IAIHG) initiated a series of research workshops to uncover the scientific gaps and opportunities in AIH. This review summarises the results of the latest workshop in Maastricht in 2022 and reviews the current challenges in adult AIH, particularly in relation to four important aspects of AIH: diagnostics; new immunomodulatory therapies; clinical trial design; and unmet clinical needs. This review also summarises the progress made since the AIH workshop in 2017. Patients and patient representatives were actively involved in the parallel working groups alongside clinicians and researchers. Despite 40 years of experience with diagnosing and treating AIH, false diagnoses occur and treatment is still based on nonselective immunosuppression. In addition to the need for more specific diagnostic tests, prognostic markers and tailor-based treatments, a major unmet clinical need was identified in areas of care delivery and health-related quality of life.",
keywords = "autoimmune hepatitis, clinical trials, diagnostics, quality of life, treatment, unmet needs, MYCOPHENOLATE-MOFETIL, DIAGNOSIS, EFFICACY, CRITERIA, THERAPY, MANAGEMENT, 2ND-LINE, DISEASE, SAFETY",
author = "R.J.A.L.M. Snijders and D.N. Assis and Y.H. Oo and M. Sebode and R. Taubert and J. Willemse and B. Tomsin and A.W. Lohse and J.P.H. Drenth and T.J.G. Gevers and {International Autoimmune Hepatitis Group (IAIHG) collaborators} and {European Reference Network for Rare Liver Diseases (ERN RARE-LIVER)}",
note = "Funding Information: This IAIHG meeting (June 2022) was supported by the European Joint Programme on Rare Diseases (EJP RD; 463001023), YAEL Foundation, University Fund Limburg (SWOL) and Netherlands Association for the Study of the Liver (NASL; NVH). YHO received funding from Sir Jules Thorn Biomedical Research Programme. This work has been generated within the European Reference Network on Hepatological Diseases (ERN RARE‐LIVER) and the International Autoimmune Hepatitis Group (IAIHG). Funding Information: We are grateful to all participants in the fourth edition of the AIH workshop in Maastricht for the fruitful discussions, and particularly to the speakers and session chairmen, namely Aldo Montano‐Loza, Alessio Gerussi, Amber Bozward, Ana Lleo, Anna Mrzljak, Anna Stoelinga, Ansgar Lohse, {\"O}zg{\"u}r Koc, Bart van Hoek, Bastian Engel, Benedetta Terziroli Beretta‐Piccoli, Christoph Schramm, Cigdem Arikan, David Assis, Femke Gevers‐Brants, George Dalekos, Girish Gupte, Johannes Hartl, Jan Philipp Weltzsch, Jeanina Kousemaker‐Nieuwdorp, Jessica Dyson, Johannes Herkel, Joost Drenth, Jos{\'e} Willemse, Bettina Langhans, Leona Dold, Maciej Janik, Marcial Sebode, Matthias Hardtke‐Wolenski, Michael Pascal Kramer, Michael Heneghan, Michele Tana, Muhammed Yuksel, Nanda Kerkar, Nicola Gagliani, Nicola Gagliani, Nikolaos Gatselis, Veronica Prado, Christian Strassburg, Richard Taubert, Robert Tomsin, Rom{\'e}e Snijders, Silja Steinmann, Simon Pape, Tom Gevers, Tony Bruns, Vincenzo Ronca, Ye Oo, Joanna Raszeja‐Wyszomirska, Ynto de Boer, Maria Antonella Burza and Jef Verbeek. We thank the International AIH Group (IAIHG) for creating a platform for international research networking and collaboration. This IAIHG meeting (June 2022) was supported by the European Joint Programme on Rare Diseases (EJP RD; 463001023), YAEL Foundation, University Fund Limburg (SWOL) and Netherlands Association for the Study of the Liver (NASL; NVH). Publisher Copyright: {\textcopyright} 2023 The Authors. Liver International published by John Wiley & Sons Ltd.",
year = "2023",
month = jul,
doi = "10.1111/liv.15573",
language = "English",
volume = "43",
pages = "1375--1384",
journal = "Liver International",
issn = "1478-3223",
publisher = "Wiley",
number = "7",
}