Rescue Left Bundle Branch Area Pacing in Coronary Venous Lead Failure or Non-response to Biventricular Pacing: Results From International LBBAP Collaborative Study Group

Pugazhendhi Vijayaraman*, Bengt Herweg, Atul Verma, Parikshit S Sharma, Syeda Atiqa Batul, Shunmuga Sundaram Ponnusamy, Robert D Schaller, Oscar Cano, Manuel Molina-Lerma, Karol Curila, Wim Huybrechts, David R Wilson, Leonard M Rademakers, Praveen Sreekumar, Gaurav Upadhyay, Kevin Vernooy, Faiz A Subzposh, Weijian Huang, Marek Jastrzebski, Kenneth A Ellenbogen

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

BACKGROUND: Cardiac resynchronization therapy (CRT) using biventricular pacing (BVP) is effective in patients with heart failure, left bundle branch block (LBBB) and reduced left ventricular function. Left bundle branch area pacing (LBBAP) has been reported as an alternative option for CRT.

OBJECTIVE: The aim of this study was to assess the feasibility and outcomes of LBBAP in patients who failed conventional BVP due to coronary venous lead complications or were non-responders to BVP.

METHODS: At 16 international centers, LBBAP was attempted in patients with conventional CRT indication who failed BVP due to either, coronary venous (CV) lead complications, or lack of therapeutic response to BVP. We are reporting heart failure hospitalizations (HFH) and death, echocardiographic outcomes, procedural data, pacing parameters, and lead complications including CV lead failure.

RESULTS: LBBAP was successfully performed in 200 patients (CV lead failures-156; non-responders-44): age 68±11years, female-35%, LBBB-55%, RVP-23%, ischemic cardiomyopathy-28%, nonischemic cardiomyopathy-63%, LVEF ≤35% in 80%. Procedure and fluoroscopy duration were 119.5±59.6 and 25.7±18.5 min. LBBAP threshold and R-wave amplitudes were 0.68±[email protected] and 10.4±5mV at implant and remained stable during mean follow-up of 12±10.1 months. LBBAP resulted in significant QRS narrowing from 170±28ms to 139±25ms (p<0.001) with V6 R-wave peak times of 85±17ms. LVEF improved from 29±10% at baseline to 40±12% (p<0.001) during follow-up. The risk for death or HFH was lower in CV lead failure compared to non-responders (HR-0.357;95%CI 0.168-0.756,p=0.007) CONCLUSION: LBBAP is a viable alternative for CRT in patients who failed conventional BVP due to CV lead failure or were non-responders.

Original languageEnglish
Pages (from-to)1272-1280
Number of pages9
JournalHeart Rhythm
Volume19
Issue number8
Early online date27 Apr 2022
DOIs
Publication statusPublished - Aug 2022

Keywords

  • Biventricular pacing failure
  • CARDIAC-RESYNCHRONIZATION THERAPY
  • Cardiac resynchronization therapy
  • Heart failure
  • Left bundle branch area pacing
  • MORBIDITY
  • MORTALITY
  • Nonresponder

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