9 Citations (Web of Science)

Abstract

Most HR-pQCT studies examining cortical bone use an automatically generated endocortical contour (AUTO), which is manually corrected if it visually deviates from the apparent endocortical margin (semi-automatic method, S-AUTO). This technique may be prone to operator-related variability and is time consuming. We examined whether the AUTO instead of the S-AUTO method can be used for cortical bone analysis. Fifty scans of the distal radius and tibia from participants of The Maastricht Study were evaluated with AUTO, and subsequently with S-AUTO by three independent operators. AUTO cortical bone parameters were compared to the average parameters obtained by the three operators (S-AUTOmean). All differences in mean cortical bone parameters between AUTO and S-AUTOmean were <5%, except for lower AUTO cortical porosity of the radius (- 16%) and tibia (- 6%), and cortical pore volume (Ct.Po.V) of the radius (- 7%). The ICC of S-AUTOmean and AUTO was > 0.90 for all parameters, except for cortical pore diameter of the radius (0.79) and tibia (0.74) and Ct.Po.V of the tibia (0.89), without systematic errors on the Bland-Altman plots. The precision errors (RMS-CV%) of the radius parameters between S-AUTOmean and AUTO were comparable to those between the individual operators, whereas the tibia RMS-CV% between S-AUTOmean and AUTO were higher than those of the individual operators. Comparison of the three operators revealed clear inter-operator variability. This study suggests that the AUTO method can be used for cortical bone analysis in a cross-sectional study, but that the absolute values-particularly of the porosity-related parameters-will be lower.

Original languageEnglish
Pages (from-to)252-265
Number of pages14
JournalCalcified Tissue International
Volume103
Issue number3
DOIs
Publication statusPublished - Sep 2018

Keywords

  • High resolution peripheral quantitative computed tomography
  • Bone microarchitecture
  • Cortical bone analysis
  • Endocortical contour
  • QUANTITATIVE COMPUTED-TOMOGRAPHY
  • IN-VIVO ASSESSMENT
  • DISTAL RADIUS
  • TRABECULAR COMPARTMENTS
  • POSTMENOPAUSAL WOMEN
  • MICROARCHITECTURE
  • PRECISION
  • POROSITY
  • QUALITY
  • TIBIA

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