Relation of surface T-wave to vulnerability to ventricular fibrillation in explanted structurally normal hearts

Marianna Meo, Pietro Bonizzi, Laura Bear, Matthijs Cluitmans, Emma Abell, Michel Haïssaguerre, Olivier Bernus, Rémi Dubois

Research output: Chapter in Book/Report/Conference proceedingConference article in proceedingAcademicpeer-review

Abstract

Introduction: Body surface characterization of repolarization gradient substrates for ventricular fibrillation (VF) is still poor. We investigated if VF propensity can be assessed from surface T-wave in an ex-vivo model of purely electrical repolarization dispersion. Methods: To create repolarization gradients, dofetilide and/or pinacidil were separately infused in N=7 isolated pig hearts in a human-shaped torso tank. At each drug state, VF inducibility was quantified by the vulnerability window (VW), i.e. the interval during which VF was triggered by S1 (atrium) S2 (ventricle) stimulation. T-wave duration (the peak-to-end interval, T-PEAK-T-END), and shape, i.e., symmetry (the ratio of the areas under the peak-to-end and onset-to-peak frames, Asy), and flatness (kurtosis, Kurt) were computed from 256 tank potentials. We fitted a linear mixed-effect (LMM) model to link T-wave markers (fixed effects) with VW (response), with random effects on drug states and hearts. Results: VF was induced in 14/23 drug states from at least one ventricle. In vulnerable substrates (higher VW), T-waves were longer (T-PEAK-T-END, p=0.0004), less symmetric (Asy, p

Original languageEnglish
Title of host publication2020 Computing in Cardiology Conference
Subtitle of host publicationP7_4a - ECG-Waveform Analysis 1
Number of pages4
Volume47
DOIs
Publication statusPublished - 2020
EventComputing in cardiology 2020 - Rimini, Rimini, Italy
Duration: 13 Sep 202016 Sep 2020

Conference

ConferenceComputing in cardiology 2020
Abbreviated titleCinC2020
Country/TerritoryItaly
CityRimini
Period13/09/2016/09/20

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