Regional effects of magnetization dispersion on quantitative perfusion imaging for pulsed and continuous arterial spin labeling

Mustafa Cavusoglu*, Rolf Pohmann, Harold Christopher Burger, Kamil Uludag

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Most experiments assume a global transit delay time with blood flowing from the tagging region to the imaging slice in plug flow without any dispersion of the magnetization. However, because of cardiac pulsation, nonuniform cross-sectional flow profile, and complex vessel networks, the transit delay time is not a single value but follows a distribution. In this study, we explored the regional effects of magnetization dispersion on quantitative perfusion imaging for varying transit times within a very large interval from the direct comparison of pulsed, pseudo-continuous, and dual-coil continuous arterial spin labeling encoding schemes. Longer distances between tagging and imaging region typically used for continuous tagging schemes enhance the regional bias on the quantitative cerebral blood flow measurement causing an underestimation up to 37% when plug flow is assumed as in the standard model. Magn Reson Med, 2013.
Original languageEnglish
Pages (from-to)524-530
JournalMagnetic Resonance in Medicine
Issue number2
Publication statusPublished - Feb 2013


  • transit delay time
  • magnetization dispersion
  • cerebral blood flow

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