Reg4(+) deep crypt secretory cells function as epithelial niche for Lgr5(+) stem cells in colon

Nobuo Sasaki, Norman Sachs, Kay Wiebrands, Saskia I. J. Ellenbroek, Arianna Fumagalli, Anna Lyubimova, Harry Begthel, Maaike van den Born, Johan H. van Es, Wouter R. Karthaus, Vivian S. W. Li, Carmen López Iglesias, Peter Peters, Jacco van Rheenen, Alexander van Oudenaarden, Hans Clevers*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

115 Citations (Web of Science)
Original languageEnglish
Pages (from-to)E5399-E5407
JournalProceedings of the National Academy of Sciences of the United States of America
Issue number37
Publication statusPublished - 13 Sep 2016


  • intestinal stem cell
  • niche
  • Lgr5
  • Reg4
  • deep crypt secretory cells

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