Reduction in IL-10 producing B cells (Breg) in multiple sclerosis is accompanied by a reduced naive/memory Breg ratio during a relapse but not in remission

S. Knippenberg, E. Peelen, J. Smolders, M.M.G.L. Thewissen, P.P.C.A. Menheere, J.W. Tervaert, R.M.M. Hupperts, J.G.M.C. Damoiseaux

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Abstract

In this study, we assessed B cell subsets, including Bregs, during stable and active disease in relapsing remitting multiple sclerosis (RRMS) patients and related B cell subsets to vitamin D status. We report that RRMS patients have a decreased percentage of both memory B cells and Bregs compared to healthy controls. During a relapse, the reduction in Bregs involved in particular naive Bregs. We found no correlation between vitamin D status and B cell subsets. An effect of vitamin D on Bregs cannot be ruled out, since it might be the function that is interfered with instead of relative numbers.
Original languageEnglish
Pages (from-to)80-86
Number of pages7
JournalJournal of Neuroimmunology
Volume239
Issue number1-2
DOIs
Publication statusPublished - 28 Oct 2011

Keywords

  • Multiple sclerosis
  • B cell
  • Regulatory B cell
  • Vitamin D
  • EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS
  • 1,25-DIHYDROXYVITAMIN D-3
  • MEMORY
  • RITUXIMAB
  • SUBSETS
  • DIFFERENTIATION
  • NATALIZUMAB
  • PROFILES

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