Abstract
In this study, we assessed B cell subsets, including Bregs, during stable and active disease in relapsing remitting multiple sclerosis (RRMS) patients and related B cell subsets to vitamin D status. We report that RRMS patients have a decreased percentage of both memory B cells and Bregs compared to healthy controls. During a relapse, the reduction in Bregs involved in particular naive Bregs. We found no correlation between vitamin D status and B cell subsets. An effect of vitamin D on Bregs cannot be ruled out, since it might be the function that is interfered with instead of relative numbers.
Original language | English |
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Pages (from-to) | 80-86 |
Number of pages | 7 |
Journal | Journal of Neuroimmunology |
Volume | 239 |
Issue number | 1-2 |
DOIs | |
Publication status | Published - 28 Oct 2011 |
Keywords
- Multiple sclerosis
- B cell
- Regulatory B cell
- Vitamin D
- EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS
- 1,25-DIHYDROXYVITAMIN D-3
- MEMORY
- RITUXIMAB
- SUBSETS
- DIFFERENTIATION
- NATALIZUMAB
- PROFILES