In this study, we assessed B cell subsets, including Bregs, during stable and active disease in relapsing remitting multiple sclerosis (RRMS) patients and related B cell subsets to vitamin D status. We report that RRMS patients have a decreased percentage of both memory B cells and Bregs compared to healthy controls. During a relapse, the reduction in Bregs involved in particular naive Bregs. We found no correlation between vitamin D status and B cell subsets. An effect of vitamin D on Bregs cannot be ruled out, since it might be the function that is interfered with instead of relative numbers.
- Multiple sclerosis
- B cell
- Regulatory B cell
- Vitamin D
- EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS
- 1,25-DIHYDROXYVITAMIN D-3
Knippenberg, S., Peelen, E., Smolders, J., Thewissen, M. M. G. L., Menheere, P. P. C. A., Tervaert, J. W., Hupperts, R. M. M., & Damoiseaux, J. G. M. C. (2011). Reduction in IL-10 producing B cells (Breg) in multiple sclerosis is accompanied by a reduced naive/memory Breg ratio during a relapse but not in remission. Journal of Neuroimmunology, 239(1-2), 80-86. https://doi.org/10.1016/j.jneuroim.2011.08.019