TY - JOUR
T1 - Reduced behavioural effectiveness of ACTH1-24 after a second administration
T2 - interaction with opiates
AU - Jolles, J.
AU - Wiegant, V.M.
AU - Gispen, W.H.
PY - 1978/1/1
Y1 - 1978/1/1
N2 - Repeated intraventricular administration of ACHT results in reduction of subsequent ACTH-induced grooming behavior. A previous injection of β-endorphin, (D-Phe7)ACTH4−10, or morphine, also reduces the behavioral response to a subsequent injection of ACTH. The reduction in grooming as a result of repeated administration is not mediated by corticosteroid feedback and can be eliminated by pretreatment with the opiate antagonist naloxone.
AB - Repeated intraventricular administration of ACHT results in reduction of subsequent ACTH-induced grooming behavior. A previous injection of β-endorphin, (D-Phe7)ACTH4−10, or morphine, also reduces the behavioral response to a subsequent injection of ACTH. The reduction in grooming as a result of repeated administration is not mediated by corticosteroid feedback and can be eliminated by pretreatment with the opiate antagonist naloxone.
U2 - 10.1016/0304-3940(78)90083-6
DO - 10.1016/0304-3940(78)90083-6
M3 - Article
SN - 0304-3940
VL - 9
SP - 261
EP - 266
JO - Neuroscience Letters
JF - Neuroscience Letters
IS - 2-3
ER -