Reduced behavioural effectiveness of ACTH1-24 after a second administration: interaction with opiates

J. Jolles, V.M. Wiegant, W.H. Gispen

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    Repeated intraventricular administration of ACHT results in reduction of subsequent ACTH-induced grooming behavior. A previous injection of β-endorphin, (D-Phe7)ACTH4−10, or morphine, also reduces the behavioral response to a subsequent injection of ACTH. The reduction in grooming as a result of repeated administration is not mediated by corticosteroid feedback and can be eliminated by pretreatment with the opiate antagonist naloxone.
    Original languageEnglish
    Pages (from-to)261-266
    Number of pages6
    JournalNeuroscience Letters
    Issue number2-3
    Publication statusPublished - 1 Jan 1978

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