Reactivity, recruitment and remodeling of collateral arteries in diabetes

M.S. Ruiter

Research output: ThesisDoctoral ThesisInternal

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Abstract

Diabetes increases the risk of peripheral arterial diasease; the consequence of arteriosclerosis in the legs, and leads to reduced mobility and a higher risk of foot wounds and amputation. This dissertation describes arteriogenesis, a natural process in which small blood vessels (collatorals) become bigger to restore the blood flow. In an animal model we show that diabetes leads to disturbed arteriogenesis. In isolated vessels we show that diabetes makes vasodilatation more difficult. Administration of a vasodilatant medicine stimulated arteriogenesis in the leg of test animals. Administering this medication could be a safe and effective treatment strategy for diabetes patients with perepherous arterial disease.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • Maastricht University
Supervisors/Advisors
  • Schaper, Nicolaas, Supervisor
  • Stehouwer, Coen, Supervisor
  • Huijberts, Maya, Advisor
  • van Golde, Jolanda, Advisor
Award date6 Sep 2012
Place of PublicationMaastricht
Publisher
Print ISBNs9789461907820
Publication statusPublished - 1 Jan 2012

Keywords

  • Diabetes
  • peripheral arterial disease
  • arteriogenesis
  • collaterals
  • vasodilatation

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