TY - JOUR
T1 - Rate and Characteristics of Incompletely Excised Cutaneous Squamous Cell Carcinoma
T2 - A Dermatological Daily Practice Multicenter Prospective Cohort Study
AU - van Lee, Charlotte B
AU - Kouloubis, Nina
AU - Wakkee, Marlies
AU - Kelleners-Smeets, Nicole W J
AU - Nellen, Ruud G L
AU - van Rengen, Annik
AU - de Vijlder, Hanke C
AU - Wijne, Leon C C
AU - Nijsten, Tamar
AU - van den Bos, Renate R
N1 - Copyright © 2022 by the American Society for Dermatologic Surgery, Inc. Published by Wolters Kluwer Health, Inc. All rights reserved.
PY - 2022/12
Y1 - 2022/12
N2 - BACKGROUND: Incomplete excision of squamous cell carcinoma (cSCC) is associated with an increased risk of recurrence, metastasis, and mortality.OBJECTIVE: To determine the rate and characteristics of incompletely excised cSCC in a dermatological daily practice setting.METHODS: Prospective study of all patients who gave informed consent, with a cSCC treated with standard excision (SE) at 1 of 6 Departments of Dermatology in the Netherlands between 2015 and 2017. Pathological reports were screened to detect all incompletely excised cSCCs.RESULTS: A total of 592 patients with 679 cSCCs were included, whereby most cases were low risk cSCC (89%). The rate of incompletely excised cSCC was 4% (n = 26), and the majority were high-risk cSCCs of which 24 invaded the deep excision margin.CONCLUSION: This prospective study showed that in a dermatological setting, the risk of an incompletely excised cSCC is low (4%) for a cohort that was dominated by low-risk cSCCs. Most incompletely excised cSCCs were of high risk, and incompleteness was almost always at the deep margins. These results suggest that for high-risk cSCC, one should pay attention especially to the deep margin when performing SE, and/or microscopic surgery should be considered.
AB - BACKGROUND: Incomplete excision of squamous cell carcinoma (cSCC) is associated with an increased risk of recurrence, metastasis, and mortality.OBJECTIVE: To determine the rate and characteristics of incompletely excised cSCC in a dermatological daily practice setting.METHODS: Prospective study of all patients who gave informed consent, with a cSCC treated with standard excision (SE) at 1 of 6 Departments of Dermatology in the Netherlands between 2015 and 2017. Pathological reports were screened to detect all incompletely excised cSCCs.RESULTS: A total of 592 patients with 679 cSCCs were included, whereby most cases were low risk cSCC (89%). The rate of incompletely excised cSCC was 4% (n = 26), and the majority were high-risk cSCCs of which 24 invaded the deep excision margin.CONCLUSION: This prospective study showed that in a dermatological setting, the risk of an incompletely excised cSCC is low (4%) for a cohort that was dominated by low-risk cSCCs. Most incompletely excised cSCCs were of high risk, and incompleteness was almost always at the deep margins. These results suggest that for high-risk cSCC, one should pay attention especially to the deep margin when performing SE, and/or microscopic surgery should be considered.
U2 - 10.1097/DSS.0000000000003606
DO - 10.1097/DSS.0000000000003606
M3 - Article
C2 - 36194767
SN - 1076-0512
VL - 48
SP - 1269
EP - 1273
JO - Dermatologic Surgery
JF - Dermatologic Surgery
IS - 12
ER -