TY - JOUR
T1 - Radiomics
T2 - from qualitative to quantitative imaging
AU - Rogers, William
AU - Seetha, Sithin Thulasi
AU - Refaee, Turkey A. G.
AU - Lieverse, Relinde I. Y.
AU - Granzier, Renee W. Y.
AU - Ibrahim, Abdalla
AU - Keek, Simon A.
AU - Sanduleanu, Sebastian
AU - Primakov, Sergey P.
AU - Beuque, Manon P. L.
AU - Marcus, Damienne
AU - van der Wiel, Alexander M. A.
AU - Zerka, Fadila
AU - Oberije, Cary J. G.
AU - van Timmeren, Janita E.
AU - Woodruff, Henry C.
AU - Lambin, Philippe
PY - 2020
Y1 - 2020
N2 - Historically, medical imaging has been a qualitative or semi-quantitative modality. It is difficult to quantify what can be seen in an image, and to turn it into valuable predictive outcomes, As a result of advances in both computational hardware and machine learning algorithms, computers are making great strides in obtaining quantitative information from imaging and correlating it with outcomes, Radiomics, in its two forms "handcrafted and deep," is an emerging field that translates medical images into quantitative data to yield biological information and enable radiologic phenotypic profiling for diagnosis, theragnosis, decision support, and monitoring. Handcrafted radiomics is a multistage process in which features based on shape, pixel intensities, and texture are extracted from radiographs. Within this review, we describe the steps: starting with quantitative imaging data, how it can be extracted, how to correlate it with clinical and biological outcomes, resulting in models that can be used to make predictions, such as survival, or for detection and classification used in diagnostics. The application of deep learning, the second arm of radiomics, and its place in the radiomics workflow is discussed, along with its advantages and disadvantages. To better illustrate the technologies being used, we provide real-world clinical applications of radiomics in oncology, showcasing research on the applications of radiomics, as well as covering its limitations and its future direction.
AB - Historically, medical imaging has been a qualitative or semi-quantitative modality. It is difficult to quantify what can be seen in an image, and to turn it into valuable predictive outcomes, As a result of advances in both computational hardware and machine learning algorithms, computers are making great strides in obtaining quantitative information from imaging and correlating it with outcomes, Radiomics, in its two forms "handcrafted and deep," is an emerging field that translates medical images into quantitative data to yield biological information and enable radiologic phenotypic profiling for diagnosis, theragnosis, decision support, and monitoring. Handcrafted radiomics is a multistage process in which features based on shape, pixel intensities, and texture are extracted from radiographs. Within this review, we describe the steps: starting with quantitative imaging data, how it can be extracted, how to correlate it with clinical and biological outcomes, resulting in models that can be used to make predictions, such as survival, or for detection and classification used in diagnostics. The application of deep learning, the second arm of radiomics, and its place in the radiomics workflow is discussed, along with its advantages and disadvantages. To better illustrate the technologies being used, we provide real-world clinical applications of radiomics in oncology, showcasing research on the applications of radiomics, as well as covering its limitations and its future direction.
KW - COMPUTER-AIDED DIAGNOSIS
KW - ABLATIVE RADIATION-THERAPY
KW - DEEP NEURAL-NETWORKS
KW - CT TEXTURE ANALYSIS
KW - FDG-PET RADIOMICS
KW - TREATMENT RESPONSE
KW - BREAST-CANCER
KW - DISTANT METASTASIS
KW - FEATURE-EXTRACTION
KW - FEATURE STABILITY
U2 - 10.1259/bjr.20190948
DO - 10.1259/bjr.20190948
M3 - (Systematic) Review article
C2 - 32101448
SN - 0007-1285
VL - 93
JO - British Journal of Radiology
JF - British Journal of Radiology
IS - 1108
M1 - 20190948
ER -