@article{cd147f542dab469ab7eca0cf63c71aab,
title = "Psychotic Experiences Are Associated With Paternal Age But Not With Delayed Fatherhood in a Large, Multinational, Community Sample",
abstract = "Advanced paternal age has been consistently associated with an increased risk of schizophrenia. It is less known if such an association also exists with subclinical/attenuated forms of psychosis. Additionally, it has been suggested that it is not paternal age per se, but rather delayed fatherhood, as a marker of a genetic liability of psychosis, that is the cause of the association. The aim of the current study was to examine whether paternal age and/or delayed fatherhood (paternity age) predict self-reported positive, negative, and/or depressive dimensions of psychosis in a large sample from the general population. The sample (N = 1465) was composed of control subjects from the 6 countries participating in the European Union Gene-Environment Interaction study. The CAPE, a self-report questionnaire, was used to measure dimensions of subclinical psychosis. Paternal age at the time of respondents' birth and age of paternity were assessed by self-report. We assessed the influence of the variables of interest (paternal age or paternity age) on CAPE scores after adjusting for potential confounders (age, gender, and ethnicity). Paternal age was positively associated with the positive dimension of the CAPE. By contrast, paternity age was not associated with any of the psychosis dimensions assessed by the CAPE. Thus, our results do not support the idea that delayed fatherhood explains the association between age of paternity and psychosis risk. Furthermore, our results provide arguments for the hypothesis of an etiologic continuum of psychosis.",
keywords = "paternal age, psychotic experiences, schizotypy, risk factors, CAPE, epidemiology, SCHIZOTYPAL DIMENSIONS, GENERAL-POPULATION, PARENTAL AGE, RISK-FACTORS, SCHIZOPHRENIA, SYMPTOMS, CONTINUUM, METAANALYSIS, MODEL, ADOLESCENTS",
author = "Franck Schurhoff and Baptiste Pignon and Mohamed Lajnef and Romain Denis and Bart Rutten and Craig Morgan and Murray, {Robin M.} and Marion Leboyer and {van Os}, Jim and Andrei Szoke",
note = "Funding Information: This work was supported by a grant (agreement HEALTH-F2-2010-241909 [Project EU-GEI]) from the European Community's Seventh Framework Programme. The authors wish to thank the members of EU-GEI WP2 group who, by participating to the design, organization and/or data collection at each site, made this work possible: Ulrich Reininghaus, Marta Di Forti, Charlotte Gayer-Anderson, Kathryn Hubbard, Stephanie Beards, Simona A. Stilo, Diego Quattrone, Giada Tripoli, Celso Arango, Mara Parellada, Miguel Bernardo, Julio Sanju{\'a}n, Julio Bobes, Manuel Arrojo, Jose Luis Santos, Pedro Cuadrado, Jos{\'e} Juan Rodr{\'i}guez Solano, Angel Carracedo, Enrique Garc{\'i}a Bernardo, Laura Rold{\'a}n, Gonzalo L{\'o}pez, Bibiana Cabrera, Esther Lorente-Rovira, Paz Garcia-Portilla, Javier Costas, Estela Jim{\'e}nez-L{\'o}pez, Mario Matteis, Marta Rapado, Emiliano Gonz{\'a}lez, Covadonga Mart{\'i}nez, Emilio S{\'a}nchez, Maria Soledad Olmeda, Lieuwe de Haan, Nathalie Franke, Eva Velthorst, Jean-Paul Selten, Daniella van Dam, Elsje van der Ven, Pierre-Michel Llorca, St{\'e}phane Jamain, Andrea Tortelli, Flora Frijda, Gr{\'e}goire Baudin, Aziz Ferchiou, Jean-Romain Richard, Thomas Charpeaud, Anne-Marie Tronche, Peter Jones, James Kirkbride, Hannah Jongsma, Ilaria Tarricone, Domenico Berardi, Daniele La Barbera, Caterina Erika La Cascia, Alice Mul{\`e}, Lucia Sideli, Rachele Sartorio, Laura Ferraro, Fabio Seminerio, Paulo R. Menezes, Cristina M. Del-Ben, Silvia H. Gallo Tenan, Rosana Shuhama, Mirella Ruggeri, Sarah Tosato. The authors have declared that there are no conflicts of interest in relation to the subject of this study. Publisher Copyright: {\textcopyright} The Author(s) 2020. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved.",
year = "2020",
month = sep,
doi = "10.1093/schbul/sbz142",
language = "English",
volume = "46",
pages = "1327--1334",
journal = "Schizophrenia Bulletin",
issn = "0586-7614",
publisher = "Oxford University Press",
number = "5",
}