Protein kinase D: at the crossroad of cardiac function and metabolism

E. Dirkx

Research output: ThesisDoctoral ThesisInternal

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Abstract

Heart failure is one of the most common causes of death. The last few years, heart failure has been associated with metabolic changes. An example is the diabetic patient; this patient often suffers from heart problems because of too much fat absorption in the heart muscle cells. This dissertation investigates how the connection between metabolism and heart function is regulated. A protein was found, protein kinase D (PKD), which steers other signal proteins that regulate the substrate balance (glucose/fat) in the heart. This balance is crucial for the maintenance of an optimal heart function. Activation of this PKD protein leads to an increase of glucose absorption, and protects the heart against the development of diabetes and heart failure during the intake of too fatty food.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • Maastricht University
Supervisors/Advisors
  • Glatz, Jan, Supervisor
  • Luiken, Joannes, Advisor
  • van Eijs, Guillaume, Advisor
Award date3 Feb 2012
Place of PublicationOisterwijk
Publisher
Print ISBNs9789088913716
Publication statusPublished - 1 Jan 2012

Keywords

  • heart failure
  • metabolism
  • PKD protein

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