TY - JOUR
T1 - Protection factors used to improve in vivo islet function
AU - Carvalho, Ana Margarida
AU - Paulino da Silva Filho, Omar
AU - van Apeldoorn, Aart
PY - 2021
Y1 - 2021
N2 - The number of preclinical studies that use drugs or endogenous factors for various targetable sites aiming to improve islet function and engraftment has recently gained more interest. Several molecules have been proposed to support and augment the functionality of islets. Here, we review five different classes of beta cell protection factors, classified as antioxidants, anti-inflammatory, anti-apoptotic, immunomodulatory, vascularization enhancers, and promoter of beta cell proliferation and function and their effect on islet grafting and function after transplantation in animal models of type 1 diabetes.
AB - The number of preclinical studies that use drugs or endogenous factors for various targetable sites aiming to improve islet function and engraftment has recently gained more interest. Several molecules have been proposed to support and augment the functionality of islets. Here, we review five different classes of beta cell protection factors, classified as antioxidants, anti-inflammatory, anti-apoptotic, immunomodulatory, vascularization enhancers, and promoter of beta cell proliferation and function and their effect on islet grafting and function after transplantation in animal models of type 1 diabetes.
U2 - 10.1016/j.regen.2021.100051
DO - 10.1016/j.regen.2021.100051
M3 - Article
SN - 2468-4988
VL - 14
JO - Journal of Immunology and Regenerative Medicine
JF - Journal of Immunology and Regenerative Medicine
M1 - 100051
ER -