Protection factors used to improve in vivo islet function

Ana Margarida Carvalho; Omar Paulino da Silva Filho; Aart van Apeldoorn

doi:10.1016/j.regen.2021.100051

Protection factors used to improve in vivo islet function

Ana Margarida Carvalho, Omar Paulino da Silva Filho, Aart van Apeldoorn^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

The number of preclinical studies that use drugs or endogenous factors for various targetable sites aiming to improve islet function and engraftment has recently gained more interest. Several molecules have been proposed to support and augment the functionality of islets. Here, we review five different classes of beta cell protection factors, classified as antioxidants, anti-inflammatory, anti-apoptotic, immunomodulatory, vascularization enhancers, and promoter of beta cell proliferation and function and their effect on islet grafting and function after transplantation in animal models of type 1 diabetes.

Original language	English
Article number	100051
Number of pages	7
Journal	Journal of Immunology and Regenerative Medicine
Volume	14
DOIs	https://doi.org/10.1016/j.regen.2021.100051
Publication status	Published - 2021

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10.1016/j.regen.2021.100051Licence: CC BY

Cite this

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title = "Protection factors used to improve in vivo islet function",

abstract = "The number of preclinical studies that use drugs or endogenous factors for various targetable sites aiming to improve islet function and engraftment has recently gained more interest. Several molecules have been proposed to support and augment the functionality of islets. Here, we review five different classes of beta cell protection factors, classified as antioxidants, anti-inflammatory, anti-apoptotic, immunomodulatory, vascularization enhancers, and promoter of beta cell proliferation and function and their effect on islet grafting and function after transplantation in animal models of type 1 diabetes.",

author = "Carvalho, {Ana Margarida} and {Paulino da Silva Filho}, Omar and {van Apeldoorn}, Aart",

year = "2021",

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AU - Paulino da Silva Filho, Omar

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DO - 10.1016/j.regen.2021.100051

M3 - Article

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