Processing of frequency and location in human subcortical auditory structures

M. Moerel, F. de Martino, K. Ugurbil, E. Yacoub, E. Formisano

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Scopus)

Abstract

To date it remains largely unknown how fundamental aspects of natural sounds, such as their spectral content and location in space, are processed in human subcortical structures. Here we exploited the high sensitivity and specificity of high field fMRI (7 Tesla) to examine the human inferior colliculus (IC) and medial geniculate body (MGB). Subcortical responses to natural sounds were well explained by an encoding model of sound processing that represented frequency and location jointly. Frequency tuning was organized in one tonotopic gradient in the IC, whereas two tonotopic maps characterized the MGB reflecting two MGB subdivisions. In contrast, no topographic pattern of preferred location was detected, beyond an overall preference for peripheral (as opposed to central) and contralateral locations. Our findings suggest the functional organization of frequency and location processing in human subcortical auditory structures, and pave the way for studying the subcortical to cortical interaction required to create coherent auditory percepts.
Original languageEnglish
Article number17048
Number of pages15
JournalScientific Reports
Volume5
DOIs
Publication statusPublished - 24 Nov 2015

Keywords

  • MEDIAL GENICULATE-BODY
  • INFERIOR COLLICULUS
  • TONOTOPIC ORGANIZATION
  • SOUND LOCALIZATION
  • 7 TESLA
  • THALAMIC NUCLEI
  • NATURAL SOUNDS
  • GUINEA-PIG
  • CAT
  • CORTEX

Cite this

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title = "Processing of frequency and location in human subcortical auditory structures",
abstract = "To date it remains largely unknown how fundamental aspects of natural sounds, such as their spectral content and location in space, are processed in human subcortical structures. Here we exploited the high sensitivity and specificity of high field fMRI (7 Tesla) to examine the human inferior colliculus (IC) and medial geniculate body (MGB). Subcortical responses to natural sounds were well explained by an encoding model of sound processing that represented frequency and location jointly. Frequency tuning was organized in one tonotopic gradient in the IC, whereas two tonotopic maps characterized the MGB reflecting two MGB subdivisions. In contrast, no topographic pattern of preferred location was detected, beyond an overall preference for peripheral (as opposed to central) and contralateral locations. Our findings suggest the functional organization of frequency and location processing in human subcortical auditory structures, and pave the way for studying the subcortical to cortical interaction required to create coherent auditory percepts.",
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author = "M. Moerel and {de Martino}, F. and K. Ugurbil and E. Yacoub and E. Formisano",
year = "2015",
month = "11",
day = "24",
doi = "10.1038/srep17048",
language = "English",
volume = "5",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",

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Processing of frequency and location in human subcortical auditory structures. / Moerel, M.; de Martino, F.; Ugurbil, K.; Yacoub, E.; Formisano, E.

In: Scientific Reports, Vol. 5, 17048, 24.11.2015.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Processing of frequency and location in human subcortical auditory structures

AU - Moerel, M.

AU - de Martino, F.

AU - Ugurbil, K.

AU - Yacoub, E.

AU - Formisano, E.

PY - 2015/11/24

Y1 - 2015/11/24

N2 - To date it remains largely unknown how fundamental aspects of natural sounds, such as their spectral content and location in space, are processed in human subcortical structures. Here we exploited the high sensitivity and specificity of high field fMRI (7 Tesla) to examine the human inferior colliculus (IC) and medial geniculate body (MGB). Subcortical responses to natural sounds were well explained by an encoding model of sound processing that represented frequency and location jointly. Frequency tuning was organized in one tonotopic gradient in the IC, whereas two tonotopic maps characterized the MGB reflecting two MGB subdivisions. In contrast, no topographic pattern of preferred location was detected, beyond an overall preference for peripheral (as opposed to central) and contralateral locations. Our findings suggest the functional organization of frequency and location processing in human subcortical auditory structures, and pave the way for studying the subcortical to cortical interaction required to create coherent auditory percepts.

AB - To date it remains largely unknown how fundamental aspects of natural sounds, such as their spectral content and location in space, are processed in human subcortical structures. Here we exploited the high sensitivity and specificity of high field fMRI (7 Tesla) to examine the human inferior colliculus (IC) and medial geniculate body (MGB). Subcortical responses to natural sounds were well explained by an encoding model of sound processing that represented frequency and location jointly. Frequency tuning was organized in one tonotopic gradient in the IC, whereas two tonotopic maps characterized the MGB reflecting two MGB subdivisions. In contrast, no topographic pattern of preferred location was detected, beyond an overall preference for peripheral (as opposed to central) and contralateral locations. Our findings suggest the functional organization of frequency and location processing in human subcortical auditory structures, and pave the way for studying the subcortical to cortical interaction required to create coherent auditory percepts.

KW - MEDIAL GENICULATE-BODY

KW - INFERIOR COLLICULUS

KW - TONOTOPIC ORGANIZATION

KW - SOUND LOCALIZATION

KW - 7 TESLA

KW - THALAMIC NUCLEI

KW - NATURAL SOUNDS

KW - GUINEA-PIG

KW - CAT

KW - CORTEX

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M3 - Article

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JO - Scientific Reports

JF - Scientific Reports

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