Prevalence of Trichomonas vaginalis infection and protozoan load in South African women: a cross-sectional study

Dewi J. de Waaij; Jan Henk Dubbink; Sander Ouburg; Remco P. H. Peters; Servaas A. Morre

doi:10.1136/bmjopen-2017-016959

Prevalence of Trichomonas vaginalis infection and protozoan load in South African women: a cross-sectional study

Dewi J. de Waaij, Jan Henk Dubbink, Sander Ouburg^*, Remco P. H. Peters, Servaas A. Morre

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Objectives Trichomonas vaginalis is thought to be the most common non-viral sexually transmitted infection worldwide. We investigated the prevalence, risk factors and protozoan load of T. vaginalis infection in South African women.

Methods A cross-sectional study of 604 women was conducted at 25 primary healthcare facilities in rural South Africa (Mopani district). T. vaginalis DNA was detected in vaginal and rectal swabs. In univariate and multivariate analyses, the T. vaginalis infection was investigated in relation to demographic characteristics, medical history and behavioural factors. The T. vaginalis load was determined as the logarithm of DNA copies per microlitre sample solution.

Results Collected vaginal and rectal swabs were tested for T. vaginalis DNA. Prevalence of vaginal T. vaginalis was 20% (95% CI 17.0% to 23.4%) and rectal 1.2% (95% CI 0.6% to 2.4%). Most women (66%) with a vaginal infection were asymptomatic. Factors associated with T. vaginalis infection were a relationship status of single (OR 2.4; 95% CI 1.5 to 4.0; p

Conclusions Vaginal trichomoniasis is highly prevalent in rural South Africa, especially among single women and those with HIV infection, and often presents without symptoms.

Original language	English
Article number	016959
Number of pages	6
Journal	BMJ Open
Volume	7
Issue number	10
DOIs	https://doi.org/10.1136/bmjopen-2017-016959
Publication status	Published - Oct 2017

Keywords

SEXUALLY-TRANSMITTED INFECTIONS
CHLAMYDIA-TRACHOMATIS
NEISSERIA-GONORRHOEAE
BACTERIAL VAGINOSIS
GENITAL-INFECTION
CLINICAL-TRIAL
RISK-FACTORS
DISEASE
DIAGNOSIS
HIV

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title = "Prevalence of Trichomonas vaginalis infection and protozoan load in South African women: a cross-sectional study",

abstract = "Objectives Trichomonas vaginalis is thought to be the most common non-viral sexually transmitted infection worldwide. We investigated the prevalence, risk factors and protozoan load of T. vaginalis infection in South African women.Methods A cross-sectional study of 604 women was conducted at 25 primary healthcare facilities in rural South Africa (Mopani district). T. vaginalis DNA was detected in vaginal and rectal swabs. In univariate and multivariate analyses, the T. vaginalis infection was investigated in relation to demographic characteristics, medical history and behavioural factors. The T. vaginalis load was determined as the logarithm of DNA copies per microlitre sample solution.Results Collected vaginal and rectal swabs were tested for T. vaginalis DNA. Prevalence of vaginal T. vaginalis was 20% (95% CI 17.0% to 23.4%) and rectal 1.2% (95% CI 0.6% to 2.4%). Most women (66%) with a vaginal infection were asymptomatic. Factors associated with T. vaginalis infection were a relationship status of single (OR 2.4; 95% CI 1.5 to 4.0; pConclusions Vaginal trichomoniasis is highly prevalent in rural South Africa, especially among single women and those with HIV infection, and often presents without symptoms.",

keywords = "SEXUALLY-TRANSMITTED INFECTIONS, CHLAMYDIA-TRACHOMATIS, NEISSERIA-GONORRHOEAE, BACTERIAL VAGINOSIS, GENITAL-INFECTION, CLINICAL-TRIAL, RISK-FACTORS, DISEASE, DIAGNOSIS, HIV",

author = "{de Waaij}, {Dewi J.} and Dubbink, {Jan Henk} and Sander Ouburg and Peters, {Remco P. H.} and Morre, {Servaas A.}",

year = "2017",

month = oct,

doi = "10.1136/bmjopen-2017-016959",

language = "English",

volume = "7",

journal = "BMJ Open",

issn = "2044-6055",

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T2 - a cross-sectional study

AU - de Waaij, Dewi J.

AU - Dubbink, Jan Henk

AU - Ouburg, Sander

AU - Peters, Remco P. H.

AU - Morre, Servaas A.

PY - 2017/10

Y1 - 2017/10

N2 - Objectives Trichomonas vaginalis is thought to be the most common non-viral sexually transmitted infection worldwide. We investigated the prevalence, risk factors and protozoan load of T. vaginalis infection in South African women.Methods A cross-sectional study of 604 women was conducted at 25 primary healthcare facilities in rural South Africa (Mopani district). T. vaginalis DNA was detected in vaginal and rectal swabs. In univariate and multivariate analyses, the T. vaginalis infection was investigated in relation to demographic characteristics, medical history and behavioural factors. The T. vaginalis load was determined as the logarithm of DNA copies per microlitre sample solution.Results Collected vaginal and rectal swabs were tested for T. vaginalis DNA. Prevalence of vaginal T. vaginalis was 20% (95% CI 17.0% to 23.4%) and rectal 1.2% (95% CI 0.6% to 2.4%). Most women (66%) with a vaginal infection were asymptomatic. Factors associated with T. vaginalis infection were a relationship status of single (OR 2.4; 95% CI 1.5 to 4.0; pConclusions Vaginal trichomoniasis is highly prevalent in rural South Africa, especially among single women and those with HIV infection, and often presents without symptoms.

AB - Objectives Trichomonas vaginalis is thought to be the most common non-viral sexually transmitted infection worldwide. We investigated the prevalence, risk factors and protozoan load of T. vaginalis infection in South African women.Methods A cross-sectional study of 604 women was conducted at 25 primary healthcare facilities in rural South Africa (Mopani district). T. vaginalis DNA was detected in vaginal and rectal swabs. In univariate and multivariate analyses, the T. vaginalis infection was investigated in relation to demographic characteristics, medical history and behavioural factors. The T. vaginalis load was determined as the logarithm of DNA copies per microlitre sample solution.Results Collected vaginal and rectal swabs were tested for T. vaginalis DNA. Prevalence of vaginal T. vaginalis was 20% (95% CI 17.0% to 23.4%) and rectal 1.2% (95% CI 0.6% to 2.4%). Most women (66%) with a vaginal infection were asymptomatic. Factors associated with T. vaginalis infection were a relationship status of single (OR 2.4; 95% CI 1.5 to 4.0; pConclusions Vaginal trichomoniasis is highly prevalent in rural South Africa, especially among single women and those with HIV infection, and often presents without symptoms.

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KW - NEISSERIA-GONORRHOEAE

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KW - CLINICAL-TRIAL

KW - RISK-FACTORS

KW - DISEASE

KW - DIAGNOSIS

KW - HIV

U2 - 10.1136/bmjopen-2017-016959

DO - 10.1136/bmjopen-2017-016959

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JO - BMJ Open

JF - BMJ Open

IS - 10

M1 - 016959

ER -

Prevalence of Trichomonas vaginalis infection and protozoan load in South African women: a cross-sectional study

Abstract

Keywords

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