TY - JOUR
T1 - Preserving Mobility in Older Adults with Physical Frailty and Sarcopenia
T2 - Opportunities, Challenges, and Recommendations for Physical Activity Interventions
AU - Billot, Maxime
AU - Calvani, Riccardo
AU - Urtamo, Annele
AU - Sanchez-Sanchez, Juan Luis
AU - Ciccolari-Micaldi, Cecilia
AU - Chang, Milan
AU - Roller-Wirnsberger, Regina
AU - Wirnsberger, Gerhard
AU - Sinclair, Alan
AU - Vaquero-Pinto, Nieves
AU - Jyvakorpi, Satu
AU - Ohman, Hanna
AU - Strandberg, Timo
AU - Schols, Jos M. G. A.
AU - Schols, Annemie M. W. J.
AU - Smeets, Nick
AU - Topinkova, Eva
AU - Michalkova, Helena
AU - Bonfigli, Anna Rita
AU - Lattanzio, Fabrizia
AU - Rodriguez-Manas, Leocadio
AU - Coelho-Junior, Helio
AU - Broccatelli, Marianna
AU - D'Elia, Maria Elena
AU - Biscotti, Damiano
AU - Marzetti, Emanuele
AU - Freiberger, Ellen
N1 - Funding Information:
The present work was funded by a grant from the Innovative Medicines Initiative—Joint Undertaking (IMI-JU 1 15621). The work was also partially supported by the nonprofit research foundation “Centro Studi Achille e Linda Lorenzon” and by intramural research grants from the Università Cattolica del Sacro Cuore (D3.2 2013 and D3.2 2015).
Funding Information:
All of the authors of the present work are partners of the SPRINTT consortium, which is partially funded by the European Federation of Pharmaceutical Industries and Associations (EFPIA). The authors report no potential conflicts of interest in this work.
Funding Information:
The present work was funded by a grant from the Innovative Medicines Initiative?Joint Undertaking (IMI-JU 115621). The work was also partially supported by the nonprofit research foundation ?Centro Studi Achille e Linda Lorenzon? and by intramural research grants from the Universit? Cattolica del Sacro Cuore (D3.2 2013 and D3.2 2015). The authors thank all the participants and the staff involved in the trial for their enthusiastic participation and dedication. The authors would like to thank Jeffrey Arsham for his revision of the English-language manuscript.
Publisher Copyright:
© 2020 Billot et al.
PY - 2020
Y1 - 2020
N2 - One of the most widely conserved hallmarks of aging is a decline in functional capabilities. Mobility loss is particularly burdensome due to its association with negative health outcomes, loss of independence and disability, and the heavy impact on quality of life. Recently, a new condition, physical frailty and sarcopenia, has been proposed to define a critical stage in the disabling cascade. Physical frailty and sarcopenia are characterized by weakness, slowness, and reduced muscle mass, yet with preserved ability to move independently. One of the strategies that have shown some benefits in combatting mobility loss and its consequences for older adults is physical activity. Here, we describe the opportunities and challenges for the development of physical activity interventions in people with physical frailty and sarcopenia. The aim of this article is to review age-related physio(patho)logical changes that impact mobility in old age and to provide recommendations and procedures in accordance with the available literature.
AB - One of the most widely conserved hallmarks of aging is a decline in functional capabilities. Mobility loss is particularly burdensome due to its association with negative health outcomes, loss of independence and disability, and the heavy impact on quality of life. Recently, a new condition, physical frailty and sarcopenia, has been proposed to define a critical stage in the disabling cascade. Physical frailty and sarcopenia are characterized by weakness, slowness, and reduced muscle mass, yet with preserved ability to move independently. One of the strategies that have shown some benefits in combatting mobility loss and its consequences for older adults is physical activity. Here, we describe the opportunities and challenges for the development of physical activity interventions in people with physical frailty and sarcopenia. The aim of this article is to review age-related physio(patho)logical changes that impact mobility in old age and to provide recommendations and procedures in accordance with the available literature.
KW - physical exercise
KW - muscle mass
KW - strength
KW - walking
KW - balance
KW - better aging
KW - SKELETAL-MUSCLE MASS
KW - GAIT SPEED
KW - BALANCE CONTROL
KW - WALKING SPEED
KW - PEOPLES PERSPECTIVES
KW - COGNITIVE DECLINE
KW - ELDERLY-PATIENTS
KW - POSTURAL CONTROL
KW - PROTEIN-INTAKE
KW - NURSING-HOME
U2 - 10.2147/CIA.S253535
DO - 10.2147/CIA.S253535
M3 - (Systematic) Review article
C2 - 32982201
SN - 1178-1998
VL - 15
SP - 1675
EP - 1690
JO - Clinical Interventions in Aging
JF - Clinical Interventions in Aging
ER -