Abstract
The majority of traumatic brain injuries (TBIs) are categorized as mild, according to a baseline Glasgow Coma Scale (GCS) score of 13-15. Prognostic models that were developed to predict functional outcome and persistent post-concussive symptoms (PPCS) after mild TBI have rarely been externally validated. We aimed to externally validate models predicting 3-12-month Glasgow Outcome Scale Extended (GOSE) or PPCS in adults with mild TBI. We analyzed data from the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) project, which included 2862 adults with mild TBI, with 6-month GOSE available for 2374 and Rivermead Post-Concussion Symptoms Questionnaire (RPQ) results available for 1605 participants. Model performance was evaluated based on calibration (graphically and characterized by slope and intercept) and discrimination (C-index). We validated five published models for 6-month GOSE and three for 6-month PPCS scores. The models used different cutoffs for outcome and some included symptoms measured 2 weeks post-injury. Discriminative ability varied substantially (C-index between 0.58 and 0.79). The models developed in the Corticosteroid Randomisation After Significant Head Injury (CRASH) trial for prediction of GOSE
Original language | English |
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Pages (from-to) | 196-209 |
Number of pages | 14 |
Journal | Journal of Neurotrauma |
Volume | 38 |
Issue number | 2 |
DOIs | |
Publication status | Published - 15 Jan 2021 |
Keywords
- external validation
- Glasgow Outcome Scale Extended
- mild traumatic brain injury
- post-concussive symptoms
- prognostic model
- RISK-FACTORS
- HEAD-INJURY
- RECOVERY
- CARE
- QUESTIONNAIRE
- EPIDEMIOLOGY
- PREVALENCE
- PREVENTION
- BIOMARKERS
- GUIDELINES