@article{d2cda8f555e445ad9452ef8956faff3c,
title = "Prediction of final infarct volume from native CT perfusion and treatment parameters using deep learning",
abstract = "CT Perfusion (CTP) imaging has gained importance in the diagnosis of acute stroke. Conventional perfusion analysis performs a deconvolution of the measurements and thresholds the perfusion parameters to determine the tissue status. We pursue a data-driven and deconvolution-free approach, where a deep neural network learns to predict the final infarct volume directly from the native CTP images and meta data such as the time parameters and treatment. This would allow clinicians to simulate various treatments and gain insight into predicted tissue status over time. We demonstrate on a multicenter dataset that our approach is able to predict the final infarct and effectively uses the metadata. An ablation study shows that using the native CTP measurements instead of the deconvolved measurements improves the prediction. (C) 2019 Published by Elsevier B.V.",
keywords = "Stroke, CT Perfusion, Final infarct prediction, Deep learning, STROKE, SALVAGE, TIME, MRI",
author = "David Robben and Boers, {Anna M. M.} and Marquering, {Henk A.} and Langezaal, {Lucianne L. C. M.} and Roos, {Yvo B. W. E. M.} and {van Oostenbrugge}, {Robert J.} and {van Zwam}, {Wim H.} and Dippel, {Diederik W. J.} and Majoie, {Charles B. L. M.} and {van der Lugt}, Aad and Robin Lemmens and Paul Suetens",
note = "Funding Information: David Robben is supported by an innovation mandate of Flanders Innovation & Entrepreneurship (VLAIO) and is an employee of Icometrix. Anna M.M. Boers, Henk A Marquering, Yvo B.W.E.M. Roos and Charles B.L.M. Majoie are shareholders of Nico.lab. Lucianne L.C.M. Langezaal, Robert J. van Oostenbrugge and Paul Suetens report no disclosures. Wim H. van Zwam reports speaker fees from Stryker and Cerenovus paid to institution. Diederik W.J. Dippel and Aad van der Lugt report funding from the Dutch Heart Foundation, Brain Foundation Netherlands, The Netherlands Organisation for Health Research and Development, Health Holland Top Sector Life Sciences & Health, and unrestricted grants from AngioCare BV, Covidien/EV3, MEDAC Gmbh/LAMEPRO, Penumbra Inc. Top Medical/Concentric, Stryker, Stryker European Operations BV, Medtronic, Thrombolytic Science, LLC for research, all paid to institution. Charles B.L.M. Majoie reports grants from European Commssion, CVON/Dutch Heart Founation, TWIN foundation, Stryker (paid to institution). Aad van der Lugt reports research grants from Siemens Healthineers, GE Healthcare and Philips Healthcare, all paid to institution. Robin Lemmens is a senior clinical investigator of FWO Flanders. The MR CLEAN trial was partly funded by the Dutch Heart Foundation and by unrestricted grants from AngioCare BV, Medtronic/Covidien/EV3Ⓡ, MEDAC Gmbh/LAMEPRO, Penumbra Inc. StrykerⓇ, and Top Medical/Concentric. Funding Information: The MR CLEAN trial was partly funded by the Dutch Heart Foundation and by unrestricted grants from AngioCare BV, Medtronic/Covidien/EV3Ⓡ, MEDAC Gmbh/LAMEPRO, Penumbra Inc., StrykerⓇ, and Top Medical/Concentric. Funding Information: David Robben is supported by an innovation mandate of Flanders Innovation & Entrepreneurship (VLAIO) and is an employee of Icometrix. Anna M.M. Boers, Henk A Marquering, Yvo B.W.E.M. Roos and Charles B.L.M. Majoie are shareholders of Nico.lab. Lucianne L.C.M. Langezaal, Robert J. van Oostenbrugge and Paul Suetens report no disclosures. Wim H. van Zwam reports speaker fees from Stryker and Cerenovus paid to institution. Diederik W.J. Dippel and Aad van der Lugt report funding from the Dutch Heart Foundation, Brain Foundation Netherlands, The Netherlands Organisation for Health Research and Development, Health Holland Top Sector Life Sciences & Health, and unrestricted grants from AngioCare BV, Covidien/EV3, MEDAC Gmbh/LAMEPRO, Penumbra Inc., Top Medical/Concentric, Stryker, Stryker European Operations BV, Medtronic, Thrombolytic Science, LLC for research, all paid to institution. Charles B.L.M. Majoie reports grants from European Commssion, CVON/Dutch Heart Founation, TWIN foundation, Stryker (paid to institution). Aad van der Lugt reports research grants from Siemens Healthineers, GE Healthcare and Philips Healthcare, all paid to institution. Robin Lemmens is a senior clinical investigator of FWO Flanders. Publisher Copyright: {\textcopyright} 2019",
year = "2020",
month = jan,
doi = "10.1016/j.media.2019.101589",
language = "English",
volume = "59",
journal = "Medical Image Analysis",
issn = "1361-8415",
publisher = "Elsevier",
}