Preclinical testing of drug delivery systems to bone

Martijn van Griensven*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

Bone defects do not heal in 5-10% of the fractures. In order to enhance bone regeneration, drug delivery systems are needed. They comprise a scaffold with or without inducing factors and/or cells. To test these drug delivery systems before application in patients, they finally need to be tested in animal models. The choice of animal model depends on the main research question; is a functional or mechanistic evaluation needed? Furthermore, which type of bone defects are investigated: load-bearing (i.e. orthopedic) or non-load-bearing (i.e. craniomaxillofacial)? This determines the type of model and in which type of animal. The experiments need to be set-up using the 3R principle and must be reported following the ARRIVE guidelines.

Original languageEnglish
Pages (from-to)151-64
Number of pages14
JournalAdvanced Drug Delivery Reviews
Volume94
DOIs
Publication statusPublished - 1 Nov 2015
Externally publishedYes

Keywords

  • Animals
  • Bone Regeneration/drug effects
  • Diphosphonates/administration & dosage
  • Disease Models, Animal
  • Drug Delivery Systems/methods
  • Drug Evaluation, Preclinical/methods
  • Humans
  • Intercellular Signaling Peptides and Proteins/administration & dosage
  • Mesenchymal Stem Cells
  • Tissue Scaffolds

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