Potential value and limitations of different clinical scoring systems in the assessment of short- and long-term outcome following orthotopic liver transplantation

Joerg Boecker, Zoltan Czigany, Jan Bednarsch, Iakovos Amygdalos, Franziska Meister, Daniel Antonio Morales Santana, Wen-Jia Liu, Pavel Strnad, Ulf Peter Neumann, Georg Lurje*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Background

In an attempt to further improve liver allograft utilization and outcome in orthotopic liver transplantation (OLT), a variety of clinical scoring systems have been developed. Here we aimed to comparatively investigate the association of the Balance-of-Risk (BAR), Survival-Outcomes-Following-Liver-Transplant (SOFT), Preallocation-Survival-Outcomes-Following-Liver-Transplant (pSOFT), Donor-Risk-Index (DRI), and the Eurotransplant-Donor-Risk-Index (ET-DRI) scores with short- and long-term outcome following OLT.

Methods

We included 338 consecutive patients, who underwent OLT in our institution between May 2010 and November 2017. For each prognostic model, the optimal cutoff values were determined with the help of the Youden-index and their diagnostic accuracy for 90-day post OLT-mortality and major postoperative complications was measured by the area under the receiver operating characteristic curve (AUROC). Patient- and graft survival were analyzed using the Kaplan-Meier method and the log-rank test. Morbidity was assessed using the Clavien-Dindo classification and the Comprehensive-Complication-Index.

Results

BAR, SOFT, and pSOFT performed well above the conventional AUROC-threshold of 0.70 with good prediction of early mortality. Only BAR showed AUC>0.70 for both mortality and major morbidity. With the cutoffs of 14, 31, and 22 respectively for BAR, SOFT, and pSOFT, subgroup analysis showed significant differences (p

Conclusions

Out of all scores tested, the BAR-score had the best value in predicting both 90-day morbidity and mortality after OLT showing the highest AUCs. The pSOFT and SOFT scores demonstrated an acceptable accuracy in predicting 90-day morbidity and mortality. The used BAR, SOFT, and pSOFT cutoffs allowed the identification of patients at risk in terms of five-year patient survival. The DRI and ET-DRI scores have failed to predict recipient outcomes in the present setting.

Original languageEnglish
Article number0214221
Number of pages15
JournalPLOS ONE
Volume14
Issue number3
DOIs
Publication statusPublished - 21 Mar 2019

Keywords

  • DONOR RISK INDEX
  • SURGICAL COMPLICATIONS
  • GRAFT FAILURE
  • SOFT SCORE
  • BAR-SCORE
  • SURVIVAL
  • ALLOCATION
  • MODEL
  • CLASSIFICATION
  • VALIDATION

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