@article{2b57435ca0cf4f38b26b9cea84a1a2c1,
title = "Population-based neuroimaging reveals traces of childbirth in the maternal brain",
abstract = "Maternal brain adaptations have been found across pregnancy and postpartum, but little is known about the long-term effects of parity on the maternal brain. Using neuroimaging and machine learning, we investigated structural brain characteristics in 12,021 middle-aged women from the UK Biobank, demonstrating that parous women showed less evidence of brain aging compared to their nulliparous peers. The relationship between childbirths and a {"}younger-looking{"} brain could not be explained by common genetic variation or relevant confounders. Although prospective longitudinal studies are needed, the results suggest that parity may involve neural changes that could influence women's brain aging later in life.",
keywords = "ALZHEIMERS-DISEASE, HIPPOCAMPAL NEUROGENESIS, MOTHERHOOD, NEUROPLASTICITY, NUMBER, PLASTICITY, PREGNANCY, REPRODUCTION, RISK, SEX-DIFFERENCES, brain imaging, genetics, machine learning, pregnancy and childbirth, Brain imaging, Pregnancy and childbirth, Machine learning, Genetics",
author = "{de Lange}, {Ann-Marie G.} and Tobias Kaufmann and {van der Meer}, Dennis and Maglanoc, {Luigi A.} and Dag Alnaes and Torgeir Moberget and Gwenaelle Douaud and Andreassen, {Ole A.} and Westlye, {Lars T.}",
note = "Funding Information: This research has been conducted using the UK Biobank under Application 27412 and received funding from the European Research Council under the European Union's Horizon 2020 research and innovation program (Grant 802998), the Research Council of Norway (286838, 273345, 249795, 276082, 223273), the South-East Norway Regional Health Authority (2015073, 2019107), and the Medical Research Council (MR/K006673/1). Funding Information: ACKNOWLEDGMENTS. This research has been conducted using the UK Biobank under Application 27412 and received funding from the European Research Council under the European Union{\textquoteright}s Horizon 2020 research and innovation program (Grant 802998), the Research Council of Norway (286838, 273345, 249795, 276082, 223273), the South-East Norway Regional Health Authority (2015073, 2019107), and the Medical Research Council (MR/K006673/1). Publisher Copyright: {\textcopyright} 2019 National Academy of Sciences. All rights reserved.",
year = "2019",
month = oct,
day = "29",
doi = "10.1073/pnas.1910666116",
language = "English",
volume = "116",
pages = "22341--22346",
journal = "Proceedings of the National Academy of Sciences of the United States of America",
issn = "0027-8424",
publisher = "National Academy of Sciences",
number = "44",
}