Polyphenol based hybrid nano-aggregates modified collagen fibers of biological valve leaflets to achieve enhanced mechanical, anticoagulation and anti-calcification properties

Shufen Li*, Shiying Lang, Zhiqian Chen*, Jingruo Chen*, Weihua Zhuang, Yangrui Du, Yawen Yao, Gongyan Liu*, Mao Chen*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Glutaraldehyde (Glut)-crosslinked porcine pericardium and bovine pericardium are mainly consisted of collagen and widely used for the preparation of heterogenous bioprosthetic heart valves (BHV), which play an important role in the replacement therapy of severe valvular heart disease, while their durability is limited by degeneration due to calcification, thrombus, endothelialization difficulty and prosthetic valve endocarditis. Herein, we develop a novel BHV, namely, TPly-BP, based on natural tannic acid and polylysine to improve the durability of Glut crosslinked bovine pericardium (Glut-BP). Impressively, tannic acid and polylysine could form nanoaggregates via multiple hydrogen bonds and covalent bonds, and the introduction of nanoaggregates not only improved the mechanical properties and collagen stability but also endowed TPly-BP with good biocompatibility and hemocompatibility. Compared to Glut-BP, TPly-BP showed significantly reduced cytotoxicity, improved endothelial cell adhesion, a low hemolysis ratio and obviously reduced platelet adhesion. Importantly, TPly-BP exhibited great antibacterial and in vivo anti-calcification ability, which was expected to improve the in vivo durability of BHVs. These results suggested that TPly-BP would be a potential candidate for BHV. Graphical abstract: [Figure not available: see fulltext.]
Original languageEnglish
Article number29
JournalJournal of Leather Science and Engineering
Volume4
Issue number1
DOIs
Publication statusPublished - 1 Dec 2022

Keywords

  • Antibacterial and anti-calcification
  • Bioprosthetic heart valve
  • Tannic acid

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