Polygenic risk scores and breast and epithelial ovarian cancer risks for carriers of BRCA1 and BRCA2 pathogenic variants

Daniel R. Barnes*, Matti A. Rookus, Lesley McGuffog, Goska Leslie, Thea M. Mooij, Joe Dennis, Nasim Mavaddat, Julian Adlard, Munaza Ahmed, Kristiina Aittomaki, Nadine Andrieu, Irene L. Andrulis, Norbert Arnold, Banu K. Arun, Jacopo Azzollini, Judith Balmana, Rosa B. Barkardottir, Daniel Barrowdale, Javier Benitez, Pascaline BerthetKatarzyna Bialkowska, Amie M. Blanco, Marinus J. Blok, Bernardo Bonanni, Susanne E. Boonen, Ake Borg, Aniko Bozsik, Angela R. Bradbury, Paul Brennan, Carole Brewer, Joan Brunet, Saundra S. Buys, Trinidad Caldes, Maria A. Caligo, Ian Campbell, Lise Lotte Christensen, Wendy K. Chung, Kathleen B. M. Claes, Chrystelle Colas, Marie-Agnes Collonge-Rame, Jackie Cook, Mary B. Daly, Rosemarie Davidson, Miguel de la Hoya, Robin de Putter, Capucine Delnatte, Peter Devilee, Orland Diez, Yuan Chun Ding, Susan M. Domchek, GEMO Study Collaborators, EMBRACE Collaborators, KConFab Investigators, HEBON Investigators, Consortium of Investigators of Modifiers of BRCA and BRCA2

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Original languageEnglish
Pages (from-to)1653-1666
Number of pages14
JournalGenetics in Medicine
Volume22
Issue number10
DOIs
Publication statusPublished - Oct 2020

Keywords

  • BRCA1
  • 2
  • breast cancer
  • ovarian cancer
  • PRS
  • genetics
  • MUTATION CARRIERS
  • SUSCEPTIBILITY
  • ASSOCIATION
  • PATHOLOGY
  • IDENTIFICATION
  • MODIFIERS
  • ALLELES
  • MODEL

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