Point-of-care testing di troponina ad alta sensibilità (hs-ctn Poct): stato dell’arte e prospettive

Margherita Morandini; Piero Cappelletti; Marco Moretti; Massimiliano Manno; Elisabetta Stenner; Lucia Malloggi; Francesca Veneziani; Maria A. Burgio; Martina Di Pietro; Maria L. Biondi; Daniela Rubin; Jessica Viola; Giulio Marino; Dina Di Maria; Deborah Mazzei; Alessio Gamboni; Dario Fina; Matteo Cassin; Gianni A. Galli; Gruppo di Studio sui Marcatori Miocardici (GdS MM) della Società Italiana di Patologia Clinica e Medicina di Laboratorio (SIPMeL)

doi:10.23736/S1825-859X.23.00173-1

Point-of-care testing di troponina ad alta sensibilità (hs-ctn Poct): stato dell’arte e prospettive

Translated title of the contribution: Hs-ctn Poct: state-of-art and clinical-organizational perspectives

Margherita Morandini^*, Piero Cappelletti, Marco Moretti, Massimiliano Manno, Elisabetta Stenner, Lucia Malloggi, Francesca Veneziani, Maria A. Burgio, Martina Di Pietro, Maria L. Biondi, Daniela Rubin, Jessica Viola, Giulio Marino, Dina Di Maria, Deborah Mazzei, Alessio Gamboni, Dario Fina, Matteo Cassin, Gianni A. Galli, Gruppo di Studio sui Marcatori Miocardici (GdS MM) della Società Italiana di Patologia Clinica e Medicina di Laboratorio (SIPMeL)

^*Corresponding author for this work

Research output: Contribution to journal › (Systematic) Review article › peer-review

Abstract

The rationale for the Point-of-care testing (POCT) of troponin (cTn) lies in the reduction of the Turnaround Time (TAT) and therefore of the length-of-stay (LOS) in the Emergency Department (ED), and in the diagnosis of heart injury in isolated areas. However, cTn POCTs are less sensitive and not comparable with laboratory methods (LAB). Their data cannot be used in the troponin curve with the LAB method and the rise and fall curve with POCT must be followed for more than 6 hours. Furthermore, there are few primary evidence and no meta-analyses on the role of cTn POCTs. Nevertheless, POCTs with hs-cTn (high-sensitivity troponin) method have recently appeared on the market and can overcome the above-described issues: PATHFAST hs-cTn, Quiedel/Alere TriageTrue, Atellica VTLi Patient-side. The Review describes the data and evidence of these devices, evaluating their adequacy for the diagnostic objectives, and their perspectives.

Translated title of the contribution	Hs-ctn Poct: state-of-art and clinical-organizational perspectives
Original language	Italian
Pages (from-to)	186-195
Number of pages	10
Journal	Rivista Italiana della Medicina di Laboratorio
Volume	18
Issue number	4
DOIs	https://doi.org/10.23736/S1825-859X.23.00173-1
Publication status	Published - 1 Dec 2022

Keywords

Acute coronary syndrome
Point-of-care testing
Troponin

Access to Document

10.23736/S1825-859X.23.00173-1

Cite this

Morandini, M., Cappelletti, P., Moretti, M., Manno, M., Stenner, E., Malloggi, L., Veneziani, F., Burgio, M. A., Di Pietro, M., Biondi, M. L., Rubin, D., Viola, J., Marino, G., Di Maria, D., Mazzei, D., Gamboni, A., Fina, D., Cassin, M., Galli, G. A., & Gruppo di Studio sui Marcatori Miocardici (GdS MM) della Società Italiana di Patologia Clinica e Medicina di Laboratorio (SIPMeL) (2022). Point-of-care testing di troponina ad alta sensibilità (hs-ctn Poct): stato dell’arte e prospettive. Rivista Italiana della Medicina di Laboratorio, 18(4), 186-195. https://doi.org/10.23736/S1825-859X.23.00173-1

@article{2a8f04e9487b4022b75c22a7815770e9,

title = "Point-of-care testing di troponina ad alta sensibilit{\`a} (hs-ctn Poct): stato dell{\textquoteright}arte e prospettive",

abstract = "The rationale for the Point-of-care testing (POCT) of troponin (cTn) lies in the reduction of the Turnaround Time (TAT) and therefore of the length-of-stay (LOS) in the Emergency Department (ED), and in the diagnosis of heart injury in isolated areas. However, cTn POCTs are less sensitive and not comparable with laboratory methods (LAB). Their data cannot be used in the troponin curve with the LAB method and the rise and fall curve with POCT must be followed for more than 6 hours. Furthermore, there are few primary evidence and no meta-analyses on the role of cTn POCTs. Nevertheless, POCTs with hs-cTn (high-sensitivity troponin) method have recently appeared on the market and can overcome the above-described issues: PATHFAST hs-cTn, Quiedel/Alere TriageTrue, Atellica VTLi Patient-side. The Review describes the data and evidence of these devices, evaluating their adequacy for the diagnostic objectives, and their perspectives.",

keywords = "Acute coronary syndrome, Point-of-care testing, Troponin",

author = "Margherita Morandini and Piero Cappelletti and Marco Moretti and Massimiliano Manno and Elisabetta Stenner and Lucia Malloggi and Francesca Veneziani and Burgio, {Maria A.} and {Di Pietro}, Martina and Biondi, {Maria L.} and Daniela Rubin and Jessica Viola and Giulio Marino and {Di Maria}, Dina and Deborah Mazzei and Alessio Gamboni and Dario Fina and Matteo Cassin and Galli, {Gianni A.} and {Gruppo di Studio sui Marcatori Miocardici (GdS MM) della Societ{\`a} Italiana di Patologia Clinica e Medicina di Laboratorio (SIPMeL)}",

note = "Publisher Copyright: {\textcopyright} 2023 EDIZIONI MINERVA MEDICA.",

year = "2022",

month = dec,

day = "1",

doi = "10.23736/S1825-859X.23.00173-1",

language = "Italian",

volume = "18",

pages = "186--195",

journal = "Rivista Italiana della Medicina di Laboratorio",

issn = "1825-859X",

publisher = "SIMeL Societa Italiana di Medicina di Laboratorio",

number = "4",

}

Morandini, M, Cappelletti, P, Moretti, M, Manno, M, Stenner, E, Malloggi, L, Veneziani, F, Burgio, MA, Di Pietro, M, Biondi, ML, Rubin, D, Viola, J, Marino, G, Di Maria, D, Mazzei, D, Gamboni, A, Fina, D, Cassin, M, Galli, GA & Gruppo di Studio sui Marcatori Miocardici (GdS MM) della Società Italiana di Patologia Clinica e Medicina di Laboratorio (SIPMeL) 2022, 'Point-of-care testing di troponina ad alta sensibilità (hs-ctn Poct): stato dell’arte e prospettive', Rivista Italiana della Medicina di Laboratorio, vol. 18, no. 4, pp. 186-195. https://doi.org/10.23736/S1825-859X.23.00173-1

TY - JOUR

T1 - Point-of-care testing di troponina ad alta sensibilità (hs-ctn Poct)

T2 - stato dell’arte e prospettive

AU - Morandini, Margherita

AU - Cappelletti, Piero

AU - Moretti, Marco

AU - Manno, Massimiliano

AU - Stenner, Elisabetta

AU - Malloggi, Lucia

AU - Veneziani, Francesca

AU - Burgio, Maria A.

AU - Di Pietro, Martina

AU - Biondi, Maria L.

AU - Rubin, Daniela

AU - Viola, Jessica

AU - Marino, Giulio

AU - Di Maria, Dina

AU - Mazzei, Deborah

AU - Gamboni, Alessio

AU - Fina, Dario

AU - Cassin, Matteo

AU - Galli, Gianni A.

AU - Gruppo di Studio sui Marcatori Miocardici (GdS MM) della Società Italiana di Patologia Clinica e Medicina di Laboratorio (SIPMeL)

PY - 2022/12/1

Y1 - 2022/12/1

N2 - The rationale for the Point-of-care testing (POCT) of troponin (cTn) lies in the reduction of the Turnaround Time (TAT) and therefore of the length-of-stay (LOS) in the Emergency Department (ED), and in the diagnosis of heart injury in isolated areas. However, cTn POCTs are less sensitive and not comparable with laboratory methods (LAB). Their data cannot be used in the troponin curve with the LAB method and the rise and fall curve with POCT must be followed for more than 6 hours. Furthermore, there are few primary evidence and no meta-analyses on the role of cTn POCTs. Nevertheless, POCTs with hs-cTn (high-sensitivity troponin) method have recently appeared on the market and can overcome the above-described issues: PATHFAST hs-cTn, Quiedel/Alere TriageTrue, Atellica VTLi Patient-side. The Review describes the data and evidence of these devices, evaluating their adequacy for the diagnostic objectives, and their perspectives.

AB - The rationale for the Point-of-care testing (POCT) of troponin (cTn) lies in the reduction of the Turnaround Time (TAT) and therefore of the length-of-stay (LOS) in the Emergency Department (ED), and in the diagnosis of heart injury in isolated areas. However, cTn POCTs are less sensitive and not comparable with laboratory methods (LAB). Their data cannot be used in the troponin curve with the LAB method and the rise and fall curve with POCT must be followed for more than 6 hours. Furthermore, there are few primary evidence and no meta-analyses on the role of cTn POCTs. Nevertheless, POCTs with hs-cTn (high-sensitivity troponin) method have recently appeared on the market and can overcome the above-described issues: PATHFAST hs-cTn, Quiedel/Alere TriageTrue, Atellica VTLi Patient-side. The Review describes the data and evidence of these devices, evaluating their adequacy for the diagnostic objectives, and their perspectives.

KW - Acute coronary syndrome

KW - Point-of-care testing

KW - Troponin

U2 - 10.23736/S1825-859X.23.00173-1

DO - 10.23736/S1825-859X.23.00173-1

M3 - (Systematic) Review article

SN - 1825-859X

VL - 18

SP - 186

EP - 195

JO - Rivista Italiana della Medicina di Laboratorio

JF - Rivista Italiana della Medicina di Laboratorio

IS - 4

ER -