Abstract
Background: We aimed to conduct a systematic review and Bayesian model-averaged meta-analysis (BMA) on the association between platelet counts and severe retinopathy of prematurity (ROP). Methods: We searched for studies reporting on platelet counts (continuous variable) or thrombocytopenia (categorical variable) and severe ROP or aggressive posterior ROP (APROP). The timing of platelet counts was divided into Phase 1 (<2 weeks) and Phase 2 (around ROP treatment). BMA was used to calculate Bayes factors (BFs). The BF10 is the ratio of the probability of the data under the alternative hypothesis (H-1) over the probability of the data under the null hypothesis (H-0). Results: We included 21 studies. BMA showed an association between low platelet counts and severe ROP. The evidence was strong (BF10 = 13.5, 7 studies) for phase 1 and very strong (BF10 = 51.0, 9 studies) for phase 2. Thrombocytopenia (<100 x 10(9)/L) in phase 2 was associated with severe ROP (BF10 = 28.2, 4 studies). Following adjustment for publication bias, only the association of severe ROP with thrombocytopenia remained with moderate evidence in favor of H-1 (BF10 = 4.30). Conclusions: Thrombocytopenia is associated with severe ROP. However, the evidence for this association was tempered when results were adjusted for publication bias.
Original language | English |
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Article number | 1903 |
Number of pages | 14 |
Journal | Children-Basel |
Volume | 10 |
Issue number | 12 |
DOIs | |
Publication status | Published - 1 Dec 2023 |
Keywords
- thrombocytopenia
- platelets
- retinopathy of prematurity
- PRETERM INFANTS
- MASS INDEX
- THROMBOCYTOPENIA
- VOLUME