Plasma myeloperoxidase is inversely associated with endothelium-dependent vasodilation in elderly subjects with abnormal glucose metabolism.

L.P. Van der Zwan, T. Teerlink, J.M. Dekker, R.M. Henry, C.D.A. Stehouwer, C. Jakobs, R.J. Heine, P.G. Scheffer

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4 Citations (Scopus)

Abstract

Myeloperoxidase (MPO), a biomarker related to inflammation, oxidative stress, and nitric oxide scavenging, has been shown to impair endothelium-dependent vasodilation. Because elevated hydrogen peroxide concentrations in diabetic vessels may enhance MPO activity, we hypothesized that a stronger association of MPO with flow-mediated dilation (FMD) may be found in subjects with abnormal glucose metabolism. Myeloperoxidase concentrations were measured in EDTA plasma samples from participants of a population-based cohort study, including 230 subjects with normal glucose metabolism and 386 with abnormal glucose metabolism. Vascular function was expressed as FMD and nitroglycerin-mediated dilation of the brachial artery. In subjects with abnormal glucose metabolism, MPO was negatively associated with FMD (-20.9 [95% confidence interval {CI}, -41.7 to -0.2] -mum change in FMD per SD increment of MPO). This association remained significant after adjustment for nitroglycerin-mediated dilation (-31.1 [95% CI, -50.0 to -12.3]) and was not attenuated after further adjustment for established risk factors. In subjects with normal glucose metabolism, MPO was not significantly associated with FMD (2.0 [95% CI, -16.0 to 20.0]). In conclusion, in subjects with abnormal glucose metabolism, plasma levels of MPO are inversely associated with endothelium-dependent vasodilation, possibly reflecting enhancement of MPO activity by vascular oxidative stress.
Original languageEnglish
Pages (from-to)1723-1729
Number of pages7
JournalMetabolism-Clinical and Experimental
Volume59
Issue number12
DOIs
Publication statusPublished - Dec 2010

Keywords

  • C-REACTIVE PROTEIN
  • FLOW-MEDIATED DILATION
  • NITRIC-OXIDE
  • DIABETES-MELLITUS
  • VITAMIN-C
  • CARDIOVASCULAR RISK
  • DISEASE
  • DYSFUNCTION
  • PREDICT
  • DETERMINANTS

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