Plasma Extracellular Vesicles as Liquid Biopsy to Unravel the Molecular Mechanisms of Cardiac Reverse Remodeling Following Resynchronization Therapy?

F.A. van Nieuwenhoven, B. Schroen, L. Barile, L. van Middendorp, F.W. Prinzen*, A. Auricchio

*Corresponding author for this work

Research output: Contribution to journal(Systematic) Review article peer-review

Abstract

Cardiac resynchronization therapy (CRT) has become a valuable addition to the treatment options for heart failure, in particular for patients with disturbances in electrical conduction that lead to regionally different contraction patterns (dyssynchrony). Dyssynchronous hearts show extensive molecular and cellular remodeling, which has primarily been investigated in experimental animals. Evidence showing that at least several miRNAs play a role in this remodeling is increasing. A comparison of results from measurements in plasma and myocardial tissue suggests that plasma levels of miRNAs may reflect the expression of these miRNAs in the heart. Because many miRNAs released in the plasma are included in extracellular vesicles (EVs), which protect them from degradation, measurement of myocardium-derived miRNAs in peripheral blood EVs may open new avenues to investigate and monitor (reverse) remodeling in dyssynchronous and resynchronized hearts of patients.
Original languageEnglish
Article number665
Number of pages11
JournalJournal of Clinical Medicine
Volume12
Issue number2
DOIs
Publication statusPublished - 1 Jan 2023

Keywords

  • microRNA
  • extracellular vesicles
  • heart failure
  • cardiac resynchronization therapy
  • dyssynchrony
  • REGULATES CARDIOMYOCYTE APOPTOSIS
  • LEFT-VENTRICULAR FUNCTION
  • HEART-FAILURE
  • CIRCULATING MICRORNA-30D
  • GENE-EXPRESSION
  • HYPERTROPHY
  • CONDUCTION
  • REPOLARIZATION
  • DYSSYNCHRONY
  • ACTIVATION

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