Pitfalls when comparing COVID-19-related outcomes across studies-lessons learnt from the ERACODA collaboration

M. Noordzij; P. Vart; R. Duivenvoorden; C.F.M. Franssen; M.H. Hemmelder; K.J. Jager; L.B. Hilbrands; R.T. Gansevoort

doi:10.1093/ckj/sfab027

Pitfalls when comparing COVID-19-related outcomes across studies-lessons learnt from the ERACODA collaboration

M. Noordzij^*, P. Vart, R. Duivenvoorden, C.F.M. Franssen, M.H. Hemmelder, K.J. Jager, L.B. Hilbrands, R.T. Gansevoort

^*Corresponding author for this work

Research output: Contribution to journal › (Systematic) Review article › peer-review

5 Citations (Web of Science)

Abstract

Reported outcomes, such as incidence rates of mortality and intensive care unit admission, vary widely across epidemiological coronavirus disease 2019 (COVID-19) studies, including in the nephrology field. This variation can in part be explained by differences in patient characteristics, but also methodological aspects must be considered. In this review, we reflect on the methodological factors that contribute to the observed variation in COVID-19-related outcomes and their risk factors that are identified in the various studies. We focus on issues that arose during the design and analysis phase of the European Renal Association COVID-19 Database (ERACODA), and use examples from recently published reports on COVID-19 to illustrate these issues.

Original language	English
Pages (from-to)	14-20
Number of pages	7
Journal	Clinical Kidney Journal
Volume	14
DOIs	https://doi.org/10.1093/ckj/sfab027
Publication status	Published - 1 Mar 2021

Keywords

COVID-19
epidemiology
kidney failure
mortality
outcomes
statistics
KIDNEY-TRANSPLANT
DIALYSIS PATIENTS
MORTALITY

Access to Document

10.1093/ckj/sfab027Licence: CC BY-NC

Cite this

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title = "Pitfalls when comparing COVID-19-related outcomes across studies-lessons learnt from the ERACODA collaboration",

abstract = "Reported outcomes, such as incidence rates of mortality and intensive care unit admission, vary widely across epidemiological coronavirus disease 2019 (COVID-19) studies, including in the nephrology field. This variation can in part be explained by differences in patient characteristics, but also methodological aspects must be considered. In this review, we reflect on the methodological factors that contribute to the observed variation in COVID-19-related outcomes and their risk factors that are identified in the various studies. We focus on issues that arose during the design and analysis phase of the European Renal Association COVID-19 Database (ERACODA), and use examples from recently published reports on COVID-19 to illustrate these issues.",

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author = "M. Noordzij and P. Vart and R. Duivenvoorden and C.F.M. Franssen and M.H. Hemmelder and K.J. Jager and L.B. Hilbrands and R.T. Gansevoort",

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AU - Noordzij, M.

AU - Vart, P.

AU - Duivenvoorden, R.

AU - Franssen, C.F.M.

AU - Hemmelder, M.H.

AU - Jager, K.J.

AU - Hilbrands, L.B.

AU - Gansevoort, R.T.

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AB - Reported outcomes, such as incidence rates of mortality and intensive care unit admission, vary widely across epidemiological coronavirus disease 2019 (COVID-19) studies, including in the nephrology field. This variation can in part be explained by differences in patient characteristics, but also methodological aspects must be considered. In this review, we reflect on the methodological factors that contribute to the observed variation in COVID-19-related outcomes and their risk factors that are identified in the various studies. We focus on issues that arose during the design and analysis phase of the European Renal Association COVID-19 Database (ERACODA), and use examples from recently published reports on COVID-19 to illustrate these issues.

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KW - epidemiology

KW - kidney failure

KW - mortality

KW - outcomes

KW - statistics

KW - KIDNEY-TRANSPLANT

KW - DIALYSIS PATIENTS

KW - MORTALITY

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