Physiology of Left Ventricular Septal Pacing and Left Bundle Branch Pacing

Research output: Contribution to journal(Systematic) Review article peer-review


Following the recognition of the adverse effects of right ventricular pacing, alternative permanent pacing strategies aiming to maintain a synchronous ventricular contraction have been sought. The quest for the optimal pacing site has recently led to several promising and rapidly emerging new pacing strategies, such as left ventricular septal pacing and left bundle branch pacing. In both animal and human studies, these pacing strategies seem to maintain electrical and mechanical activation of the left ventricle to a (near)physiologic level. However, more studies on the long-term effects of both strategies are needed.

Original languageEnglish
Pages (from-to)181-189
Number of pages9
JournalCardiac Electrophysiology Clinics
Issue number2
Publication statusPublished - Jun 2022


  • Bundle of His
  • Bundle-Branch Block/therapy
  • Cardiac Pacing, Artificial/adverse effects
  • Cardiac Resynchronization Therapy
  • Electrocardiography
  • Heart Conduction System
  • Heart Ventricles
  • Humans

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