Physical performance and sarcopenia assessment in patients with a recent fracture visiting the Fracture Liaison Service

UNLABELLED: Impaired physical performance is associated with increased fracture risk. Performance on four physical functioning tests and prevalence of sarcopenia were assessed for 1789 fracture patients and compared to reference data. Performance was low on all tests, especially for patients with a hip, major or ≥1 prevalent vertebral fracture. PURPOSE INTRODUCTION: Impaired physical performance and sarcopenia are associated with increased fracture risk. This study aims to assess physical performance and the prevalence of sarcopenia in patients with a recent clinical fracture attending the Fracture Liaison Service (FLS) compared to population means. METHODS: In this cross-sectional study, chair stand test (CST), handgrip strength (HGS), timed-up-and-go (TUG), 6-min walking-test (6MWT), and sarcopenia (following EWGSOP2) were assessed. The proportion of patients with impaired/poor performance compared to reference data was calculated (Z-score: ≥ - 2SD to < -1 (impaired) and < -2 SD (poor)). Associations of fracture type, sex, age, and time since fracture with Z-scores were assessed using linear regression analyses. RESULTS: A total of 1789 consecutive FLS patients were included (median age (IQR): 66 (59-74), 70.7% females, 3.9 (±1.6) months after fracture). The prevalence of impaired/poor performance for CST, HGS, TUG, and 6MWT was 39.2%, 30.4%, 21.9%, and 71.5%, respectively (expected proportion of 16%) and 2.8% had sarcopenia. Lower Z-scores (P < 0.001) were found for hip, major, and  ≥1 prevalent vertebral fracture (VF) in CST (major: regression coefficient (B) (95%CI) = -0.25 [-0.34, -0.16]; hip: B =-0.32 [-0.47, -0.17], VF: B =-0.22 [-0.34, -0.11]), TUG; (major: B = -0.54 [-0.75, -0.33]; hip: B = -1.72 [-2.08, -1.35], VF: B = -0.61 [-0.88, -0.57]), 6MWT (major: B =-0.34 [-0.47, -0.21]; hip: B = -0.99 [-1,22, -0.77], VF: B = -0.36 [-0.53, -0.19]). CONCLUSIONS: Physical performance is significantly lower in FLS patients compared to healthy peers, especially in patients with hip, major or prevalent VF. These findings underline the need to assess and improve the physical performance of FLS patients, despite a low prevalence of sarcopenia.