Pharmacological modulation of vascular ageing: a review from VascAgeNet

Lynn Roth; Soner Dogan; Bilge Guvenc Tuna; Tamas Aranyi; Sonia Benitez; Maria Borrell-Pages; Perinur Bozaykut; Guido R Y De Meyer; Laurent Duca; Nergiz Durmus; Diogo Fonseca; Emil Fraenkel; Philippe Gillery; Alessandro Giudici; Stéphane Jaisson; Madeleine Johansson; Josep Julve; Angela K Lucas-Herald; Wim Martinet; Pascal Maurice; Barry McDonnell; Emine Nur Ozbek; Giacomo Pucci; Christopher J A Pugh; Keith D Rochfort; Anton J M Roks; Noemi Rotllan; James Shadiow; Yahya Sohrabi; Bart Spronck; Flora Szeri; Dimitrios Terentes-Printzios; Elif Tunç Aydin; Olga Tura-Ceide; Eda Ucar; Gunay Yetik Anacak

doi:10.1016/j.arr.2023.102122

Pharmacological modulation of vascular ageing: a review from VascAgeNet

Lynn Roth^*, Soner Dogan, Bilge Guvenc Tuna, Tamas Aranyi, Sonia Benitez, Maria Borrell-Pages, Perinur Bozaykut, Guido R Y De Meyer, Laurent Duca, Nergiz Durmus, Diogo Fonseca, Emil Fraenkel, Philippe Gillery, Alessandro Giudici, Stéphane Jaisson, Madeleine Johansson, Josep Julve, Angela K Lucas-Herald, Wim Martinet, Pascal MauriceBarry McDonnell, Emine Nur Ozbek, Giacomo Pucci, Christopher J A Pugh, Keith D Rochfort, Anton J M Roks, Noemi Rotllan, James Shadiow, Yahya Sohrabi, Bart Spronck, Flora Szeri, Dimitrios Terentes-Printzios, Elif Tunç Aydin, Olga Tura-Ceide, Eda Ucar, Gunay Yetik Anacak^*

^*Corresponding author for this work

Research output: Contribution to journal › (Systematic) Review article › peer-review

Abstract

Vascular ageing, characterized by structural and functional changes in blood vessels of which arterial stiffness and endothelial dysfunction are key components, is associated with increased risk of cardiovascular and other age-related diseases. As the global population continues to age, understanding the underlying mechanisms and developing effective therapeutic interventions to mitigate vascular ageing becomes crucial for improving cardiovascular health outcomes. Therefore, this review provides an overview of the current knowledge on pharmacological modulation of vascular ageing, highlighting key strategies and promising therapeutic targets. Several molecular pathways have been identified as central players in vascular ageing, including oxidative stress and inflammation, the renin-angiotensin-aldosterone system, cellular senescence, macroautophagy, extracellular matrix remodelling, calcification, and gasotransmitter-related signalling. Pharmacological and dietary interventions targeting these pathways have shown potential in ameliorating age-related vascular changes. Nevertheless, the development and application of drugs targeting vascular ageing is complicated by various inherent challenges and limitations, such as certain preclinical methodological considerations, interactions with exercise training and sex/gender-related differences, which should be taken into account. Overall, pharmacological modulation of endothelial dysfunction and arterial stiffness as hallmarks of vascular ageing, holds great promise for improving cardiovascular health in the ageing population. Nonetheless, further research is needed to fully elucidate the underlying mechanisms and optimize the efficacy and safety of these interventions for clinical translation.

Original language	English
Article number	102122
Number of pages	23
Journal	Ageing research reviews
Volume	92
Issue number	1
DOIs	https://doi.org/10.1016/j.arr.2023.102122
Publication status	Published - 11 Nov 2023

Keywords

Vascular ageing
arterial stiffness
drugs
endothelial dysfunction
nutrition
pharmacology

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10.1016/j.arr.2023.102122Licence: CC BY-NC

Cite this

Roth, L., Dogan, S., Tuna, B. G., Aranyi, T., Benitez, S., Borrell-Pages, M., Bozaykut, P., De Meyer, G. R. Y., Duca, L., Durmus, N., Fonseca, D., Fraenkel, E., Gillery, P., Giudici, A., Jaisson, S., Johansson, M., Julve, J., Lucas-Herald, A. K., Martinet, W., ... Anacak, G. Y. (2023). Pharmacological modulation of vascular ageing: a review from VascAgeNet. Ageing research reviews, 92(1), Article 102122. https://doi.org/10.1016/j.arr.2023.102122

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title = "Pharmacological modulation of vascular ageing: a review from VascAgeNet",

abstract = "Vascular ageing, characterized by structural and functional changes in blood vessels of which arterial stiffness and endothelial dysfunction are key components, is associated with increased risk of cardiovascular and other age-related diseases. As the global population continues to age, understanding the underlying mechanisms and developing effective therapeutic interventions to mitigate vascular ageing becomes crucial for improving cardiovascular health outcomes. Therefore, this review provides an overview of the current knowledge on pharmacological modulation of vascular ageing, highlighting key strategies and promising therapeutic targets. Several molecular pathways have been identified as central players in vascular ageing, including oxidative stress and inflammation, the renin-angiotensin-aldosterone system, cellular senescence, macroautophagy, extracellular matrix remodelling, calcification, and gasotransmitter-related signalling. Pharmacological and dietary interventions targeting these pathways have shown potential in ameliorating age-related vascular changes. Nevertheless, the development and application of drugs targeting vascular ageing is complicated by various inherent challenges and limitations, such as certain preclinical methodological considerations, interactions with exercise training and sex/gender-related differences, which should be taken into account. Overall, pharmacological modulation of endothelial dysfunction and arterial stiffness as hallmarks of vascular ageing, holds great promise for improving cardiovascular health in the ageing population. Nonetheless, further research is needed to fully elucidate the underlying mechanisms and optimize the efficacy and safety of these interventions for clinical translation.",

keywords = "Vascular ageing, arterial stiffness, drugs, endothelial dysfunction, nutrition, pharmacology",

author = "Lynn Roth and Soner Dogan and Tuna, {Bilge Guvenc} and Tamas Aranyi and Sonia Benitez and Maria Borrell-Pages and Perinur Bozaykut and {De Meyer}, {Guido R Y} and Laurent Duca and Nergiz Durmus and Diogo Fonseca and Emil Fraenkel and Philippe Gillery and Alessandro Giudici and St{\'e}phane Jaisson and Madeleine Johansson and Josep Julve and Lucas-Herald, {Angela K} and Wim Martinet and Pascal Maurice and Barry McDonnell and Ozbek, {Emine Nur} and Giacomo Pucci and Pugh, {Christopher J A} and Rochfort, {Keith D} and Roks, {Anton J M} and Noemi Rotllan and James Shadiow and Yahya Sohrabi and Bart Spronck and Flora Szeri and Dimitrios Terentes-Printzios and Aydin, {Elif Tun{\c c}} and Olga Tura-Ceide and Eda Ucar and Anacak, {Gunay Yetik}",

year = "2023",

month = nov,

day = "11",

doi = "10.1016/j.arr.2023.102122",

language = "English",

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journal = "Ageing research reviews",

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Roth, L, Dogan, S, Tuna, BG, Aranyi, T, Benitez, S, Borrell-Pages, M, Bozaykut, P, De Meyer, GRY, Duca, L, Durmus, N, Fonseca, D, Fraenkel, E, Gillery, P, Giudici, A, Jaisson, S, Johansson, M, Julve, J, Lucas-Herald, AK, Martinet, W, Maurice, P, McDonnell, B, Ozbek, EN, Pucci, G, Pugh, CJA, Rochfort, KD, Roks, AJM, Rotllan, N, Shadiow, J, Sohrabi, Y, Spronck, B, Szeri, F, Terentes-Printzios, D, Aydin, ET, Tura-Ceide, O, Ucar, E & Anacak, GY 2023, 'Pharmacological modulation of vascular ageing: a review from VascAgeNet', Ageing research reviews, vol. 92, no. 1, 102122. https://doi.org/10.1016/j.arr.2023.102122

TY - JOUR

T1 - Pharmacological modulation of vascular ageing

T2 - a review from VascAgeNet

AU - Roth, Lynn

AU - Dogan, Soner

AU - Tuna, Bilge Guvenc

AU - Aranyi, Tamas

AU - Benitez, Sonia

AU - Borrell-Pages, Maria

AU - Bozaykut, Perinur

AU - De Meyer, Guido R Y

AU - Duca, Laurent

AU - Durmus, Nergiz

AU - Fonseca, Diogo

AU - Fraenkel, Emil

AU - Gillery, Philippe

AU - Giudici, Alessandro

AU - Jaisson, Stéphane

AU - Johansson, Madeleine

AU - Julve, Josep

AU - Lucas-Herald, Angela K

AU - Martinet, Wim

AU - Maurice, Pascal

AU - McDonnell, Barry

AU - Ozbek, Emine Nur

AU - Pucci, Giacomo

AU - Pugh, Christopher J A

AU - Rochfort, Keith D

AU - Roks, Anton J M

AU - Rotllan, Noemi

AU - Shadiow, James

AU - Sohrabi, Yahya

AU - Spronck, Bart

AU - Szeri, Flora

AU - Terentes-Printzios, Dimitrios

AU - Aydin, Elif Tunç

AU - Tura-Ceide, Olga

AU - Ucar, Eda

AU - Anacak, Gunay Yetik

PY - 2023/11/11

Y1 - 2023/11/11

N2 - Vascular ageing, characterized by structural and functional changes in blood vessels of which arterial stiffness and endothelial dysfunction are key components, is associated with increased risk of cardiovascular and other age-related diseases. As the global population continues to age, understanding the underlying mechanisms and developing effective therapeutic interventions to mitigate vascular ageing becomes crucial for improving cardiovascular health outcomes. Therefore, this review provides an overview of the current knowledge on pharmacological modulation of vascular ageing, highlighting key strategies and promising therapeutic targets. Several molecular pathways have been identified as central players in vascular ageing, including oxidative stress and inflammation, the renin-angiotensin-aldosterone system, cellular senescence, macroautophagy, extracellular matrix remodelling, calcification, and gasotransmitter-related signalling. Pharmacological and dietary interventions targeting these pathways have shown potential in ameliorating age-related vascular changes. Nevertheless, the development and application of drugs targeting vascular ageing is complicated by various inherent challenges and limitations, such as certain preclinical methodological considerations, interactions with exercise training and sex/gender-related differences, which should be taken into account. Overall, pharmacological modulation of endothelial dysfunction and arterial stiffness as hallmarks of vascular ageing, holds great promise for improving cardiovascular health in the ageing population. Nonetheless, further research is needed to fully elucidate the underlying mechanisms and optimize the efficacy and safety of these interventions for clinical translation.

AB - Vascular ageing, characterized by structural and functional changes in blood vessels of which arterial stiffness and endothelial dysfunction are key components, is associated with increased risk of cardiovascular and other age-related diseases. As the global population continues to age, understanding the underlying mechanisms and developing effective therapeutic interventions to mitigate vascular ageing becomes crucial for improving cardiovascular health outcomes. Therefore, this review provides an overview of the current knowledge on pharmacological modulation of vascular ageing, highlighting key strategies and promising therapeutic targets. Several molecular pathways have been identified as central players in vascular ageing, including oxidative stress and inflammation, the renin-angiotensin-aldosterone system, cellular senescence, macroautophagy, extracellular matrix remodelling, calcification, and gasotransmitter-related signalling. Pharmacological and dietary interventions targeting these pathways have shown potential in ameliorating age-related vascular changes. Nevertheless, the development and application of drugs targeting vascular ageing is complicated by various inherent challenges and limitations, such as certain preclinical methodological considerations, interactions with exercise training and sex/gender-related differences, which should be taken into account. Overall, pharmacological modulation of endothelial dysfunction and arterial stiffness as hallmarks of vascular ageing, holds great promise for improving cardiovascular health in the ageing population. Nonetheless, further research is needed to fully elucidate the underlying mechanisms and optimize the efficacy and safety of these interventions for clinical translation.

KW - Vascular ageing

KW - arterial stiffness

KW - drugs

KW - endothelial dysfunction

KW - nutrition

KW - pharmacology

U2 - 10.1016/j.arr.2023.102122

DO - 10.1016/j.arr.2023.102122

M3 - (Systematic) Review article

SN - 1872-9649

VL - 92

JO - Ageing research reviews

JF - Ageing research reviews

IS - 1

M1 - 102122

ER -