PET staging of amyloidosis using striatum

Bernard J. Hanseeuw*, Rebecca A. Betensky, Elizabeth C. Mormino, Aaron P. Schultz, Jorge Sepulcre, John A. Becker, Heidi I. L. Jacobs, Rachel F. Buckley, Molly R. LaPoint, Patrizia Vannini, Nancy J. Donovan, Jasmeer P. Chhatwal, Gad A. Marshall, Kathryn Papp, Rebecca E. Amariglio, Dorene M. Rentz, Reisa A. Sperling, Keith A. Johnson, Alzheimers Dis Neuroimaging Initia; Harvard Aging Brain Study

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

64 Citations (Web of Science)

Abstract

Introduction: Amyloid positron emission tomography (PET) data are commonly expressed as binary measures of cortical deposition. However, not all individuals with high cortical amyloid will experience rapid cognitive decline. Motivated by postmortem data, we evaluated a three-stage PET classification: low cortical; high cortical, low striatal; and high cortical, high striatal amyloid; hypothesizing this model could better reflect Alzheimer's dementia progression than a model based only on cortical measures. Methods: We classified PET data from 1433 participants (646 normal, 574 mild cognitive impairment, and 213 AD), explored the successive involvement of cortex and striatum using 3-year follow-up PET data, and evaluated the associations between PET stages, hippocampal volumes, and cognition. Results: Follow-up data indicated that PET detects amyloid first in cortex and then in striatum. Our three-category staging including striatum better predicted hippocampal volumes and subsequent cognition than a three-category staging including only cortical amyloid. Discussion: PET can evaluate amyloid expansion from cortex to subcortex. Using striatal signal as a marker of advanced amyloidosis may increase predictive power in Alzheimer's dementia research. (C) 2018 The Authors. Published by Elsevier Inc. on behalf of the Alzheimer's Association.
Original languageEnglish
Pages (from-to)1281-1292
Number of pages12
JournalAlzheimer's & Dementia
Volume14
Issue number10
DOIs
Publication statusPublished - 1 Oct 2018

Keywords

  • Amyloid PET imaging
  • Structural MRI
  • Striatum
  • Cortex
  • Cognitive aging
  • MCI
  • Alzheimer's disease
  • Classification
  • Staging
  • MILD COGNITIVE IMPAIRMENT
  • PITTSBURGH COMPOUND B
  • PRECLINICAL ALZHEIMER-DISEASE
  • NEUROIMAGING INITIATIVE ADNI
  • A-BETA
  • PROSPECTIVE COHORT
  • COMPOSITE SCORE
  • HUMAN BRAIN
  • DEPOSITION
  • DECLINE

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