Personal influencing factors for pressure pain threshold in healthy people: A systematic review and meta-analysis

S. Vervullens; V. Haenen; L. Meert; M. Meeus; R.J.E.M. Smeets; I. Baert; M.G.C.A.M. Mertens

doi:10.1016/j.neubiorev.2022.104727

Personal influencing factors for pressure pain threshold in healthy people: A systematic review and meta-analysis

S. Vervullens, V. Haenen, L. Meert, M. Meeus^*, R.J.E.M. Smeets, I. Baert, M.G.C.A.M. Mertens

^*Corresponding author for this work

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Abstract

All studies that investigated personal factors influencing pressure pain threshold (PPT) in healthy people were synthesized. Data was summarized, and risk of bias (RoB) and level of evidence were determined. Results were pooled per influencing factor, grouped by body region and included in meta-analyses. Fifty-four studies were eligible. Five had low, nine moderate, and 40 high RoB. Following meta-analyses, a strong conclusion was found for the influence of scapular position, a moderate for the influence of gender, and a weak for the influence of age (shoulder/arm region) and blood pressure on PPT. In addition, body mass index, gender (leg region), alcohol consumption and pain vigilance may not influence PPT. Based on qualitative summary, depression and meno-pause may not influence PPT. For other variables there was only preliminary or conflicting evidence. However, caution is advised, since the majority of included studies showed a high RoB and several were not eligible to include in meta-analyses. Heterogeneity was high in the performed meta-analyses, and most conclusions were weak. More standardized research is necessary.

Original language	English
Article number	104727
Number of pages	40
Journal	Neuroscience and Biobehavioral Reviews
Volume	139
DOIs	https://doi.org/10.1016/j.neubiorev.2022.104727
Publication status	Published - 1 Aug 2022

Keywords

Pain
Pressure pain threshold
Normative values
Healthy people
Influencing factors
FUNNEL PLOT ASYMMETRY
SEX-DIFFERENCES
ETHNIC-DIFFERENCES
MENSTRUAL-CYCLE
BLOOD-PRESSURE
YOUNG-ADULT
SENSITIVITY
AGE
GENDER
RESPONSES

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10.1016/j.neubiorev.2022.104727

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title = "Personal influencing factors for pressure pain threshold in healthy people: A systematic review and meta-analysis",

abstract = "All studies that investigated personal factors influencing pressure pain threshold (PPT) in healthy people were synthesized. Data was summarized, and risk of bias (RoB) and level of evidence were determined. Results were pooled per influencing factor, grouped by body region and included in meta-analyses. Fifty-four studies were eligible. Five had low, nine moderate, and 40 high RoB. Following meta-analyses, a strong conclusion was found for the influence of scapular position, a moderate for the influence of gender, and a weak for the influence of age (shoulder/arm region) and blood pressure on PPT. In addition, body mass index, gender (leg region), alcohol consumption and pain vigilance may not influence PPT. Based on qualitative summary, depression and meno-pause may not influence PPT. For other variables there was only preliminary or conflicting evidence. However, caution is advised, since the majority of included studies showed a high RoB and several were not eligible to include in meta-analyses. Heterogeneity was high in the performed meta-analyses, and most conclusions were weak. More standardized research is necessary.",

keywords = "Pain, Pressure pain threshold, Normative values, Healthy people, Influencing factors, FUNNEL PLOT ASYMMETRY, SEX-DIFFERENCES, ETHNIC-DIFFERENCES, MENSTRUAL-CYCLE, BLOOD-PRESSURE, YOUNG-ADULT, SENSITIVITY, AGE, GENDER, RESPONSES",

author = "S. Vervullens and V. Haenen and L. Meert and M. Meeus and R.J.E.M. Smeets and I. Baert and M.G.C.A.M. Mertens",

note = "Funding Information: The study was not financially supported by any study sponsor. S.V. is a predoctoral research fellow of BOF UAntwerp, Belgium, and L.M. and V.H. are predoctoral research fellows of the FWO-Flanders, Belgium. Publisher Copyright: {\textcopyright} 2022 Elsevier Ltd",

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doi = "10.1016/j.neubiorev.2022.104727",

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TY - JOUR

T1 - Personal influencing factors for pressure pain threshold in healthy people: A systematic review and meta-analysis

AU - Vervullens, S.

AU - Haenen, V.

AU - Meert, L.

AU - Meeus, M.

AU - Smeets, R.J.E.M.

AU - Baert, I.

AU - Mertens, M.G.C.A.M.

N1 - Funding Information: The study was not financially supported by any study sponsor. S.V. is a predoctoral research fellow of BOF UAntwerp, Belgium, and L.M. and V.H. are predoctoral research fellows of the FWO-Flanders, Belgium. Publisher Copyright: © 2022 Elsevier Ltd

PY - 2022/8/1

Y1 - 2022/8/1

N2 - All studies that investigated personal factors influencing pressure pain threshold (PPT) in healthy people were synthesized. Data was summarized, and risk of bias (RoB) and level of evidence were determined. Results were pooled per influencing factor, grouped by body region and included in meta-analyses. Fifty-four studies were eligible. Five had low, nine moderate, and 40 high RoB. Following meta-analyses, a strong conclusion was found for the influence of scapular position, a moderate for the influence of gender, and a weak for the influence of age (shoulder/arm region) and blood pressure on PPT. In addition, body mass index, gender (leg region), alcohol consumption and pain vigilance may not influence PPT. Based on qualitative summary, depression and meno-pause may not influence PPT. For other variables there was only preliminary or conflicting evidence. However, caution is advised, since the majority of included studies showed a high RoB and several were not eligible to include in meta-analyses. Heterogeneity was high in the performed meta-analyses, and most conclusions were weak. More standardized research is necessary.

AB - All studies that investigated personal factors influencing pressure pain threshold (PPT) in healthy people were synthesized. Data was summarized, and risk of bias (RoB) and level of evidence were determined. Results were pooled per influencing factor, grouped by body region and included in meta-analyses. Fifty-four studies were eligible. Five had low, nine moderate, and 40 high RoB. Following meta-analyses, a strong conclusion was found for the influence of scapular position, a moderate for the influence of gender, and a weak for the influence of age (shoulder/arm region) and blood pressure on PPT. In addition, body mass index, gender (leg region), alcohol consumption and pain vigilance may not influence PPT. Based on qualitative summary, depression and meno-pause may not influence PPT. For other variables there was only preliminary or conflicting evidence. However, caution is advised, since the majority of included studies showed a high RoB and several were not eligible to include in meta-analyses. Heterogeneity was high in the performed meta-analyses, and most conclusions were weak. More standardized research is necessary.

KW - Pain

KW - Pressure pain threshold

KW - Normative values

KW - Healthy people

KW - Influencing factors

KW - FUNNEL PLOT ASYMMETRY

KW - SEX-DIFFERENCES

KW - ETHNIC-DIFFERENCES

KW - MENSTRUAL-CYCLE

KW - BLOOD-PRESSURE

KW - YOUNG-ADULT

KW - SENSITIVITY

KW - AGE

KW - GENDER

KW - RESPONSES

U2 - 10.1016/j.neubiorev.2022.104727

DO - 10.1016/j.neubiorev.2022.104727

M3 - (Systematic) Review article

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VL - 139

JO - Neuroscience and Biobehavioral Reviews

JF - Neuroscience and Biobehavioral Reviews

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