Peri-procedural thrombocytopenia after aortic bioprosthesis implant: A systematic review and meta-analysis comparison among conventional, stentless, rapid-deployment, and transcatheter valves

Federica Jiritano*, Giuseppe Santarpino, Giuseppe Filiberto Serraino, Hugo Ten Cate, Matteo Matteucci, Dario Fina, Pasquale Mastroroberto, Roberto Lorusso

*Corresponding author for this work

Research output: Contribution to journal(Systematic) Review article peer-review

12 Citations (Web of Science)


Background: Thrombocytopenia has been shown to occur soon after surgical biological aortic valve replacement (AVR), and recently reported also after transcatheter valve implantation (TAVI). The mechanism underlying this phenomenon is still unknown, and its clinical impact on the peri-operative outcome has been poorly investigated.

Methods: A systematic review and a meta-analysis of all available studies reporting data about periprocedural thrombocytopenia on isolated bio-AVR, comparing rapid-deployment (RDV), stentless (stentless-AVR), and TAVI vs. stented (stented-AVR) valves, have been performed.

Results: Fifteen trials (2.163 patients) were included in the meta-analysis. Perioperative platelet reduction ranged from 35% to 55% in stented-AVR, from 60% to 77% in stentless-AVR, from 53% to 60% in RDV, and from to 21% to 72% in TAVI (apparently, balloon-expandable valves more frequently associated to thrombocytopenia). Stented-AVR required more red blood cells transfusion than stentless-AVR (P <0.0001), whereas no difference has been found between RDV and stented-AVR. Platelet transfusion rate was very low in all surgical groups. No difference has been found in RDV and stentless-AVR vs. stented-AVR, in terms of reoperation for bleeding, and length-of-intensive care unit or hospital stay.

Conclusions: Thrombocytopenia-related major adverse events were mainly reported in TAVI patients, whereas clinically meaningless in surgical patients. Transient peri-procedural thrombocytopenia is common after bio-AVR, regardless of prosthesis's type or implant modality. It should receive appropriate monitoring and focused investigations. (C) 2019 The Authors. Published by Elsevier B.V.

Original languageEnglish
Pages (from-to)43-50
Number of pages8
JournalInternational Journal of Cardiology
Publication statusPublished - 1 Dec 2019


  • Platelet
  • Thrombocytopenia
  • Aortic valve replacement
  • Trans-catheter aortic valve implantation
  • Bleeding
  • TAVI

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