PDE Inhibition and cognition enhancement

A. Blokland, F. S. Menniti, J. Prickaerts

Research output: Contribution to journalArticleAcademicpeer-review

22 Citations (Scopus)

Abstract

There has been an increasing interest in the development of phosphodiesterase (PDE) inhibitors for the treatment of cognitive dysfunctions. In this editorial, the mechanism of action of PDEs is briefly described, while the effects of different PDE inhibitors in preclinical models are reviewed. Based on the expression of PDE mRNA in the human brain, it is suggested that PDE1 and PDE10 inhibitors are strong candidates for the development of cognition enhancers. However, the complex nature of the expression of PDEs in the brain warrants further research into the role of PDEs in the signaling pathways in brain circuits. The development of PDE inhibitors, which are selective for PDE splicing isoforms, may be promising for future drug development.
Original languageEnglish
Pages (from-to)349-354
Number of pages6
JournalExpert Opinion on Therapeutic Patents
Volume22
Issue number4
DOIs
Publication statusPublished - Apr 2012

Keywords

  • brain
  • cAMP
  • cGMP
  • cognition
  • memory
  • phosphodiesterase
  • SELECTIVE PHOSPHODIESTERASE INHIBITORS
  • CYCLIC-NUCLEOTIDE PHOSPHODIESTERASES
  • LONG-TERM POTENTIATION
  • DIFFERENT MECHANISMS
  • MEMORY
  • BRAIN
  • CGMP
  • SCHIZOPHRENIA
  • RECOGNITION
  • HIPPOCAMPUS

Cite this

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abstract = "There has been an increasing interest in the development of phosphodiesterase (PDE) inhibitors for the treatment of cognitive dysfunctions. In this editorial, the mechanism of action of PDEs is briefly described, while the effects of different PDE inhibitors in preclinical models are reviewed. Based on the expression of PDE mRNA in the human brain, it is suggested that PDE1 and PDE10 inhibitors are strong candidates for the development of cognition enhancers. However, the complex nature of the expression of PDEs in the brain warrants further research into the role of PDEs in the signaling pathways in brain circuits. The development of PDE inhibitors, which are selective for PDE splicing isoforms, may be promising for future drug development.",
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PDE Inhibition and cognition enhancement. / Blokland, A.; Menniti, F. S.; Prickaerts, J.

In: Expert Opinion on Therapeutic Patents, Vol. 22, No. 4, 04.2012, p. 349-354.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

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AU - Blokland, A.

AU - Menniti, F. S.

AU - Prickaerts, J.

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KW - brain

KW - cAMP

KW - cGMP

KW - cognition

KW - memory

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KW - CYCLIC-NUCLEOTIDE PHOSPHODIESTERASES

KW - LONG-TERM POTENTIATION

KW - DIFFERENT MECHANISMS

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KW - CGMP

KW - SCHIZOPHRENIA

KW - RECOGNITION

KW - HIPPOCAMPUS

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