Patient-specific affect-abdominal pain interactions in endometriosis: an experience sampling method (ESM) study

E. van Barneveld*, M. de Hertogh, L. Vork, N. van Hanegem, F.H.M. van Osch, J.W. Kruimel, M.Y. Bongers, C. Leue, A.C. Lim

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Objectives Cross-sectional studies show that endometriosis-related pain is associated with affect. Measuring these symptoms in real-time in a longitudinal perspective yields the ability to analyze the temporal relationship between variables. The aim was to evaluate the association between affect and abdominal pain, using the Experience Sampling Method (ESM) as a real-time, randomly repeated assessment. Methods Thirty-four endometriosis patients and 31 healthy subjects completed up to 10 real-time self-assessments concerning abdominal pain and affective symptoms during seven consecutive days. Results Endometriosis patients experienced more abdominal pain and negative affective symptoms, and scored lower on positive affect compared to healthy controls. A significant association was found between abdominal pain and both positive and negative affect in endometriosis patients. For healthy controls, less strong or non-significant associations were found. When looking at abdominal pain as a predictor for affect and vice versa, we found that only in endometriosis patients, pain was subsequently accompanied by negative affect, and positive affect may alleviate pain in these patients. Conclusions This study confirms a concurrent and temporal relationship between affect and abdominal pain in endometriosis patients and supports the use of real-time symptom assessment to interpret potential influencers of abdominal complaints in patients with endometriosis.
Original languageEnglish
Pages (from-to)237-243
Number of pages7
JournalJournal of Psychosomatic Obstetrics and Gynecology
Issue number3
Early online date23 Mar 2022
Publication statusPublished - 3 Jul 2022


  • Endometriosis
  • momentary assessment
  • experience sampling method
  • positive affect
  • negative effect
  • pain
  • depression
  • anxiety
  • LIFE

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