Pathophysiology of the right ventricle and of the pulmonary circulation in pulmonary hypertension: an update

Anton Vonk Noordegraaf*, Kelly Marie Chin, Francois Haddad, Paul M. Hassoun, Anna R. Hemnes, Susan Roberta Hopkins, Steven Mark Kawut, David Langleben, Joost Lumens, Robert Naeije

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

177 Citations (Web of Science)

Abstract

The function of the right ventricle determines the fate of patients with pulmonary hypertension. Since right heart failure is the consequence of increased afterload, a full physiological description of the cardiopulmonary unit consisting of both the right ventricle and pulmonary vascular system is required to interpret clinical data correctly. Here, we provide such a description of the unit and its components, including the functional interactions between the right ventricle and its load. This physiological description is used to provide a framework for the interpretation of right heart catheterisation data as well as imaging data of the right ventricle obtained by echocardiography or magnetic resonance imaging. Finally, an update is provided on the latest insights in the pathobiology of right ventricular failure, including key pathways of molecular adaptation of the pressure overloaded right ventricle. Based on these outcomes, future directions for research are proposed.

Original languageEnglish
Article number1801900
Number of pages13
JournalEuropean Respiratory Journal
Volume53
Issue number1
DOIs
Publication statusPublished - 1 Jan 2019
Event6th World Symposium on Pulmonary Hypertension: what’s old is new - Nice, France
Duration: 27 Feb 20181 Mar 2018

Keywords

  • RIGHT HEART-FAILURE
  • HEALTHY-HUMAN LUNG
  • ARTERIAL-HYPERTENSION
  • PRESSURE-VOLUME
  • BLOOD-FLOW
  • EXERCISE HEMODYNAMICS
  • PROGNOSTIC RELEVANCE
  • VASCULAR-RESISTANCE
  • CLINICAL-RELEVANCE
  • EJECTION FRACTION

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